Eco-friendly synthesis of zinc oxide nanoparticle using Centella asiatica: phytochemical analysis, characterization and antimicrobial activity assessment

Authors

  • Bhoj Raj Poudel Department of Chemistry, Tri Chandra Multiple Campus, Tribhuvan University, Kathmandu, Nepal
  • Laxmi Tiwari Department of Chemistry, Tri Chandra Multiple Campus, Tribhuvan University, Kathmandu, Nepal
  • Chunu Magar Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Sujan Dhungana Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Aayush Raj Poudel Patan Academy of Health Sciences, Lalitpur, Nepal
  • Devendra Khadka Tribhuvan Multiple Campus, Tribhuvan University, Tansen, Palpa, Nepal
  • Megh Raj Pokhrel Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal
  • Janaki Baral Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu

DOI:

https://doi.org/10.3126/sw.v18i18.78439

Keywords:

Antifungal, Antimicrobial, C. asiatica, Nanoparticles, Phytochemicals

Abstract

Zinc oxide nanoparticles (ZnO NPs) were synthesized using an eco-friendly approach, utilizing the aqueous extracts of Centella asiatica (C. asiatica), a perennial herbaceous plant with important therapeutic uses, locally called 'Ghodtapre' in Nepali. In this work, plant extracts from C. asiatica were used to produce ZnO NPs in an environmentally friendly manner. ZnO NPs were characterized through X-ray diffraction (XRD), UV-visible spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. A noticeable absorption peak at 375 nm, which agrees with a band gap of 2.80 eV, was determined by UV analysis. The FTIR analysis confirmed the existence of functional groups that serve as capping and stabilizing agents. XRD analysis estimated 11.74 nm of the crystallite size of the ZnO NPs. According to phytochemical studies, flavonoids, tannins, quinine, terpenoids, and alkaloids are all present. Antimicrobial testing confirms the nanoparticles' effectiveness against both bacteria and fungi.

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Published

2025-06-10

How to Cite

Poudel, B. R., Tiwari, L., Magar, C., Dhungana, S., Poudel, A. R., Khadka, D., … Baral, J. (2025). Eco-friendly synthesis of zinc oxide nanoparticle using Centella asiatica: phytochemical analysis, characterization and antimicrobial activity assessment. Scientific World, 18(18), 39–46. https://doi.org/10.3126/sw.v18i18.78439

Issue

Vol. 18 No. 18 (2025)

Section

Research Article