Hospital-based Analytical Study of Anti-thyroid Peroxidase Titre Among Type-2 Diabetic Patients Suffering from Thyroid Disorders

  • Rajneesh Jha Birat Medical College Teaching Hospital, Nepal https://orcid.org/0000-0003-4921-7801
  • Amit Mishra Goverment District Hospital, Udaypur, Nepal
  • Meena Kumari Mishra Chitwan Medical College
  • Ram Lala Mallick Birat Medical College Teaching Hospital, Nepal
Keywords: Anti-TPO, thyroid stimulating hormone, total triiodothyronine, thyroxine, type-2 diabetes.

Abstract

Introduction: Thyroid hormones control growth, development and metabolic processes. Either excessive or deficient secretion of these hormones interfere with metabolism. Thyroid hormones, therefore, can alter a person's blood sugar. Relatively, thyroid peroxidise enzyme plays a key role in thyroid hormone production. The individuals who suffer from autoimmune thyroid diseases produce auto antibodies against thyroid peroxidise (called anti-TPO).

Objectives: We aimed to investigate an association of anti-TPO titer among type-2 diabetic patients suffering from thyroid disorders attending the local hospital.

Methodology: Based on findings of thyroid variables [such as total triiodothyronine (TT3 ), thyroxine (T4 ) and thyroid stimulated  hormone (TSH)], type-2 diabetic patients were categorized into Euthyroidism, Subclinical hypothyroidism and Hypothyroidism. In this hospital-based prospective study, venipuncture was performed to collect anti-cubital venous blood samples (n=100) from January to December, 2018. After separation of sera, estimation of certain parameters such as TT3, T4 , TSH and anti-TPO were carried out for correlative analyses. In this aspect, based on WHO guidelines, the patients who had fasting as well as postprandial blood sugar levels > 126 and 200 mg/dl were confirmed for diabetes mellitus. In addition, if these patients exhibited HbA1C levels > 10.8 %, they were enrolled into the 1 study. The patients who were hyperglycemic (with fasting as well as post-prandial blood sugar levels < 126 and 200 mg/dl) were excluded.

Results: In the three groups as stated above, we observed that more a rise in level of glucose, greater were the values of TSH and anti-TPO.

Conclusion Such findings emphasize and put an impact in situations of thyroid abnormality among type-2 local diabetic population.

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Author Biographies

Rajneesh Jha, Birat Medical College Teaching Hospital, Nepal

Department of Internal Medicine

Amit Mishra, Goverment District Hospital, Udaypur, Nepal

Department of Emergency Medicine

Meena Kumari Mishra, Chitwan Medical College

Department of Prosthodontics and Maxillofacial Prosthetics

Ram Lala Mallick, Birat Medical College Teaching Hospital, Nepal

Department of Biochemistry

Published
2019-05-03
How to Cite
Jha, R., Mishra, A., Mishra, M., & Mallick, R. (2019). Hospital-based Analytical Study of Anti-thyroid Peroxidase Titre Among Type-2 Diabetic Patients Suffering from Thyroid Disorders. Birat Journal of Health Sciences, 4(1), 660-665. https://doi.org/10.3126/bjhs.v4i1.23948
Section
Original Research Articles