Evaluation of the Effect of Single Bolus Dose of Intravenous Dexmedetomidine in Spinal Anaesthesia for Lower Limb Surgeries

  • Bandana Paudel Nobel Medical College and Teaching Hospital https://orcid.org/0000-0001-8225-0983
  • Pramod Rai Nobel Medical College and Teaching Hospital
  • Robins Tiwari Nobel Medical College and Teaching Hospital
  • Sanjay Gautam Nobel Medical College and Teaching Hospital
  • Sumitra Paudel Nobel Medical College and Teaching Hospital
  • - Shubham Nobel Medical College and Teaching Hospital
Keywords: Adjuvants; analgesia; bupivacaine; dexmedetomidine; lower extremity; pain management; spinal anesthesia

Abstract

Introduction: The use of intrathecal adjuvants in spinal anaesthesia in enhancing and prolonging it’s action has been well established and is widely used for surgery below the umbilicus. Dexmedetomidine, a selective α2A receptor agonist is a suitable adjuvant due to its selective activity.

Objectives: To evaluate the effect of a single bolus dose of intravenous dexmedetomidine as an adjuvant in cases undergoing lower limb surgeries under spinal anaesthesia.

Methodology: One hundred patients posted for lower limb surgery under spinal anaesthesia with hyperbaric bupivacaine, were equally divided into two groups. In group D, in addition to spinal, intravenous dexmedetomidine 0.5mcg/kg over 10 min was given whereas group C patients received spinal and intravenous normal saline .

Results: The onset of sensory and motor block was faster in group D (2.09 ± 0.71 min, 3.18 ± 1min)compared to group C (3.5 ± 0.82 min, 6.19 ± 1.87 min) which was statistically significant . The duration of sensory and motor block was also significantly prolonged in Group D (174.5 ± 14.04 min, 133.4 ± 10.42 min) as compared to Group C(138.2 ± 11.51 min, 120.4 ± 8.8 min).The duration of analgesia in Group D (225.3 ±20.11 min)was prolonged when compared to Group C (168.3 ± 15.11).

Conclusion: Intravenous dexmedetomidine as a single bolus dose before spinal anaesthesia can fasten the onset of sensory and motor block, prolongs the duration of sensory and motor block and also increased the duration of analgesia.

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Author Biographies

Bandana Paudel, Nobel Medical College and Teaching Hospital

Assistant Professor, Department of Anesthesiology, Critical care and Pain medicine

Pramod Rai, Nobel Medical College and Teaching Hospital

Consultant, Department of Anesthesiology, Critical care and Pain medicine

Robins Tiwari, Nobel Medical College and Teaching Hospital

Resident, Department of Anesthesiology, Critical care and Pain medicine

Sanjay Gautam, Nobel Medical College and Teaching Hospital

Resident, Department of Anesthesiology, Critical care and Pain medicine

Sumitra Paudel, Nobel Medical College and Teaching Hospital

Medical Officer, Department of Anesthesiology, Critical care and Pain medicine

- Shubham, Nobel Medical College and Teaching Hospital

Consultant, Department of Anesthesiology, Critical care and Pain medicine

Published
2020-06-26
How to Cite
Paudel, B., Rai, P., Tiwari, R., Gautam, S., Paudel, S., & Shubham, -. (2020). Evaluation of the Effect of Single Bolus Dose of Intravenous Dexmedetomidine in Spinal Anaesthesia for Lower Limb Surgeries. Birat Journal of Health Sciences, 5(1), 970-975. https://doi.org/10.3126/bjhs.v5i1.29636
Section
Original Research Articles