Utility of Triglyceride-Glucose index in predicting glycemic control in type 2 diabetes mellitus

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DOI:

https://doi.org/10.3126/bjhs.v6i2.40308

Keywords:

Glycemic control, Triglyceride glucose index, Type 2 diabetes mellitus

Abstract

Introduction: Insulin resistance (IR) and glycemic control are two very important aspects to be considered during management of patients with Type 2 Diabetes Mellitus (T2DM). The triglyceride-glucose (TyG) index has been proposed as a simple and inexpensive parameter that correlates well with IR and glycemic control.

Objectives: To explore the association of TyG index (and other TyG derived indices) with glycated hemoglobin (HbA1c) and evaluate their predictive ability for glycemic control in patients with T2DM.

Methodology: This cross-sectional study comprised of 160 adult patients diagnosed with T2DM visiting the medical outpatient department of Chitwan Medical College, Bharatpur, Chitwan between July–December 2019. Socio-demographic data and anthropometric measurements were collected. Glycemic control was assessed by HbA1c. TyG index was calculated by the formula: ln [fasting TG (mg/dl) x fasting glucose (mg/dl)/2]. Receiver operating characteristic (ROC) curve analysis was performed to analyze the predictive ability of TyG-index for poor glycemic control.

Results: One hundred and sixty patients (mean age: 53.6 ± 10.7 years, 55.0% males) were included in the study. Eighty (50.0%) had good glycemic control (HbA1c <7.0%). TyG index, along with TyG-BMI and TyG-WC (other TyG derived indices) were significantly increased in the poor glycemic control group. TyG index had a good predictive ability for poor glycemic control (AUC: 0.803, 95% CI: 0.731 – 0.874). A TyG cutoff ≥ 9.12 was optimal for predicting poor glycemic control, with 86.1% sensitivity and 61.5% specificity.

Conclusion: TyG index could be a simple and cost-effective screening tool for assessment of glycemic control in patients with T2DM.

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Author Biographies

Santosh Timalsina, Chitwan Medical College

Assistant Professor, Department of Biochemistry

Shishir Mahato, Chitwan Medical College

Student, Department of Laboratory Medicine

Sandesh Nepal, Chitwan Medical College

Student, Department of Laboratory Medicine

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Published

2021-11-03

How to Cite

Timalsina, S. ., Mahato, S. ., & Nepal, S. . (2021). Utility of Triglyceride-Glucose index in predicting glycemic control in type 2 diabetes mellitus. Birat Journal of Health Sciences, 6(2), 1444–1448. https://doi.org/10.3126/bjhs.v6i2.40308

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Section

Original Research Articles