Lymphocyte-Neutrophil Ratio in the Diagnosis of Tubercular Pleural Effusion in a Tertiary Care Centre: A Descriptive Cross Sectional Study

Authors

  • Rajneesh Jha Birat Medical College and Teaching Hospital, Nepal https://orcid.org/0000-0003-4921-7801
  • Ram Kumar Mehata Birat Medical College and Teaching Hospital, Nepal
  • Puru Koirala Birat Medical College and Teaching Hospital, Nepal, Nepal

DOI:

https://doi.org/10.3126/bjhs.v6i2.40351

Keywords:

LN ratio, ADA, exudative effusion

Abstract

Introduction: Tuberculosis is a common infection in our community. Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis. Among the several causes of exudative pleural effusison tubercular remains the most common form in clinical practice. The aim of this study was to evaluate the significance of lymphocyte-neutrophil ratio(LN ratio) in cases of exudative effusion for diagnosis of tubercular effusion.

Methods: This was a hospital based cross sectional studydone in Patients at tertiary care hospital from 1st September 2020 to 1st april 2021after taking ethical clearance from institutional reviw committee. Convienience samplingwas done. Statistical Analysis of data like percentages and frequencies  were used for categorical variables. Mean and SD (standard deviation) were used for describing continuous variables. Inferential statistical tools like Chi-Square test and Student’s t-test were used. P-value of <0.05 was considered statistically significant.

Results: out of 200 cases 75% were tubercular pleural effusion and these cases were found have high levels of LN ratio (0.89 ± 0.11 for females and 0.97 ± 0.14 for males) and ADA (137.79 ± 44.61for females and 147.61 ± 51.64 for males) and more than 90% sensitivity and specificity of LN ratio and ADA level.

Conclusion: Exudative pleural fluid L/N ratio >0.75 is an efficient means of diagnosing tuberculous pleural effusion and its combination with ADA level gives us more accuracy and surety about the diagnosis of tubercular pleural effusion.

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Author Biographies

Rajneesh Jha, Birat Medical College and Teaching Hospital, Nepal

Assistant Professor, Department of Internal Medicine

Ram Kumar Mehata, Birat Medical College and Teaching Hospital, Nepal

Lecturer, Department of Internal Medicine

Puru Koirala, Birat Medical College and Teaching Hospital, Nepal, Nepal

Associate Professor, Department of Internal Medicine

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Published

2021-11-03

How to Cite

Jha, R. ., Mehata, R. K. ., & Koirala, P. . (2021). Lymphocyte-Neutrophil Ratio in the Diagnosis of Tubercular Pleural Effusion in a Tertiary Care Centre: A Descriptive Cross Sectional Study. Birat Journal of Health Sciences, 6(2), 1517–1521. https://doi.org/10.3126/bjhs.v6i2.40351

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Section

Original Research Articles