TY - JOUR AU - Joshi, Kriti AU - KC, Anadi Khatri AU - Rijal, Roshija Khanal AU - Rai, Salma KC AU - Lammichane, Gyanendra AU - Yadav, Roshan Dev PY - 2020/06/26 Y2 - 2024/03/28 TI - Compliance and Visual Outcome Of “Treat-And-Extend” Versus “Pro Re Nata”Dosing of Intravitreal Bevacizumab in Wet Age-Related Macular Degeneration – A Perspective From a Developing Country JF - Birat Journal of Health Sciences JA - Birat J. Health Sci. VL - 5 IS - 1 SE - Original Research Articles DO - 10.3126/bjhs.v5i1.29614 UR - https://www.nepjol.info/index.php/bjhs/article/view/29614 SP - 921-926 AB - <p><strong>Introduction: </strong>Age- related Macular Degeneration (AMD) is the commonest cause of irreversible blindness and visual impairment in elderly, aged50 years or older contributing 8.7% of global blindness. Among the two types: “dry” and “wet”, the “wet” variant is treated using anti-VEGFs, mainly via two regimen – PRN or TREX.</p><p><strong>Objective: </strong>To study and compare the compliance, cost and visual outcome of “Treat-and- Extend (TREX)”versus “Pro Re Nata(PRN)” dosing of intravitrealbevacizumab in Wet AMD.</p><p><strong>Methodology: </strong>Sixty-four eyes of 64 patients with treatment naïve neovascular AMD were included and randomly divided into two groups, with each group comprising 32 eyes, by lottery system: “Group A [TREX]” and “Group B [PRN]”. Group A was treated with intravitrealbevacizumab [1.25mg/0.05ml] at presentation and at 1-month interval for 3 consecutive months [loading dose] and monthly till dry macula was obtained. Group B was treated with the same in “as needed” basis.Both Groups were followed up, for 1 year.</p><p><strong>Results<br> </strong>Mean gain in visual acuity in the PRN group was 0.09 +/- 0.35 log MAR unit and in TREX, it was 0.14 +/- 0.3 log MAR unit within the period of 1 year.64% of the patients were compliant in TREX and 36% moderately complaint whereas in the PRN group, 24% were compliant, 60% moderately compliant and 16% noncompliant. Average hospital cost in PRN and TREX was NRs. 16, 170 (USD 149) and 23,785(USD 220) respectively.</p><p><strong>Conclusion: </strong>Compliance and visual outcome were better in TREX in comparison toPRN at 1 year of treatment with intravitrealbevacizumab for Wet AMD.</p> ER -