Adequacy of Thyroid Homone Replacement in a Tertiary Care Hospital in Nepal-An Observational Study

Authors

  • H.K. Shrestha Siddha Baba Superspeciality Hospital Butwal, Nepal
  • R. Tamrakar Kathmandu University Hospital, Dhulikhel Hospital, Nepal
  • A. Shrestha Kathmandu University Hospital, Dhulikhel Hospital, Nepal
  • M. Uprety Birta City Hospital, Birtamode, Nepal
  • B. Shrestha Helping Hand Hospital, Chabahil, Nepal

DOI:

https://doi.org/10.3126/jdean.v5i1.38802

Keywords:

Primary Hypothyroidism, Treatment Outcome, Levothyroxin

Abstract

Background: The therapeutic goal in hypothyroidism is to achieve patients’ well-being and restore serum thyrotropin (TSH) to levels within the reference range. However, inadequate or over replacement is common in patients receiving levothyroxine. The Objective is to assess the treatment outcome of hypothyroid patients visiting outpatient clinic of medicine department of Kathmandu University Hospital, Dhulikhel, Nepal.

Method: This is a cross sectional study on diagnosed Primary Hypothyroid patients who were taking levothyroxine replacement for at least six months. Patients were defined as euthyoid if their TSH was in the normal range (0.3-3.6 mmol/L) according to the hospital laboratory. Similarly patients were defined as over treated if TSH is <0.3 mmol/L and undertreated if TSH is >3.6 mmol/L.

Results: A total number of 126 patients were enrolled for this study where mean age of participants was 40.88 ± 11.47 years and only 15 (11.1%) were male. Mean duration of hypothyroidism was 3.45 ± 2.57 years and mean Levothyroxine dose was 58.93 ± 26.89 mcg. In this study, nearly 70% of participants have normal TSH level. Similarly, 21% of participants have higher level of TSH and 9% have low TSH level. Multivariate logistic regression analysis did not show any significant co relation between treatment outcome and various variables.

Conclusion: Treatment of hypothyroidism with levothyroxine being most effective, easily available, simple regimen and not costly, still one third of patients are not meeting the treatment outcome. However, being the pioneer study from Nepal, this study suggests improved treatment outcomes compared to similar studies from other countries.

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Author Biographies

H.K. Shrestha, Siddha Baba Superspeciality Hospital Butwal, Nepal

Consultant Endocrinologist, Physician

R. Tamrakar, Kathmandu University Hospital, Dhulikhel Hospital, Nepal

Lecturer

A. Shrestha, Kathmandu University Hospital, Dhulikhel Hospital, Nepal

Lecturer

M. Uprety, Birta City Hospital, Birtamode, Nepal

Medical Officer

B. Shrestha, Helping Hand Hospital, Chabahil, Nepal

Medical Officer

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Published

2021-08-05

How to Cite

Shrestha, H., Tamrakar, R., Shrestha, A., Uprety, M., & Shrestha, B. (2021). Adequacy of Thyroid Homone Replacement in a Tertiary Care Hospital in Nepal-An Observational Study. Journal of Diabetes and Endocrinology Association of Nepal, 5(1), 33–38. https://doi.org/10.3126/jdean.v5i1.38802

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Section

Original Articles