Sleep Disordered Breathing in Patient with Type 2 Diabetes Mellitus and its Association with Diabetic Retinopathy: Single Center Study

  • Milesh Jung Sijapati KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal https://orcid.org/0000-0001-6797-4764
  • Minalma Pandey Swacon International Hospital and Sleep Care Center, Kathmandu, Nepal
  • Poojyashree Karki KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal
  • Nirupama Khadka Swacon International Hospital and sleep center, Kathmandu, Nepal
Keywords: Apnea, Diabetes, Glycosylated, Haemoglobin, Obstructive sleep apnea, Polysomnography, Retinopathy

Abstract

Introduction: Sleep-disordered breathing comprises of obstructive sleep apnea, central sleep apnea, and periodic breathing. There is a link between obesity diabetes and sleep apnea with its association with retinopathy. Therefore this study was done to find out the association of sleep-disordered breathing in uncontrolled diabetes mellitus and association with retinopathy.
Materials and Methods: This study was done from 2015 September to 2018 September in Sleep center, Nepal.  Patients diagnosed with Type 2 diabetes mellitus were included. Diabetes mellitus was diagnosed as blood sugar fasting ≥ 126mg/dl, or blood sugar postprandial ≥200mg/dl and glycosylated hemoglobin above 6.5%. Obstructive sleep apnea risk was determined using the STOP-BANG questionnaire. Relationships between the risk of Obstructive sleep apnea and clinical variables along with its association with diabetic retinopathy were evaluated using bivariate analyses and covariate-adjusted logistic regression models.
Results: A total of 150 diabetic patients were analyzed. Among them 30 (20.0%) patients had mild Obstructive sleep apnea, 14 (9.3%) patients had moderate Obstructive sleep apnea and 15 (10.0%) patients had severe sleep apnea. Among patients with diabetes mellitus on multivariate regression analysis Obstructive sleep apnea was associated with diabetes mellitus OR 2.05, 95% CI (1.69- 8.83) and diabetic retinopathy OR 1.20 (0.67-5.89).
Conclusions: This study concludes that those individuals having diabetes may be suffering from obstructive sleep apnea and association with retinopathy these individuals can be considered for the screening of sleep-disordered breathing by polysomnography.

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Author Biographies

Milesh Jung Sijapati, KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal

Associate Professor; Department of Internal Medicine

Minalma Pandey, Swacon International Hospital and Sleep Care Center, Kathmandu, Nepal

Cardiology Department

Poojyashree Karki, KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal

Department of Ophthalmology

Published
2019-06-20
How to Cite
Sijapati, M., Pandey, M., Karki, P., & Khadka, N. (2019). Sleep Disordered Breathing in Patient with Type 2 Diabetes Mellitus and its Association with Diabetic Retinopathy: Single Center Study. Nepalese Medical Journal, 2(1), 160-163. https://doi.org/10.3126/nmj.v2i1.23546
Section
Original Articles