Histopathological Spectrum of Non-neoplastic and Neoplastic Lesions of Urinary Bladder

Authors

  • Manisha Shrestha Patan Academy of Health Sciences, Lalitpur, Nepal https://orcid.org/0000-0003-2313-6835
  • Dipti Gautam Patan Academy of Health Sciences, Lalitpur, Nepal
  • Prakriti Shah Patan Academy of Health Sciences, Lalitpur, Nepal
  • Prateek Krishna Shrestha Nidan Hospital, Lalitpur, Nepal

DOI:

https://doi.org/10.3126/nmj.v4i2.41353

Keywords:

Carcinoma, Cystectomy, Cysto, Urinary bladder

Abstract

Introduction: Urinary bladder is a site of various non-neoplastic and neoplastic lesions, both of which can present with hematuria. Cystoscopy allows for direct visualization of the bladder mucosa and also obtaining tissue for histopathologic evaluation. The most common non-neoplastic and neoplastic lesion of the urinary bladder is non-specific cystitis and urothelial carcinoma respectively.

Materials and methods: This study is a 4-year retrospective study conducted in the Department of Pathology at Patan Hospital, Nepal. All cases from the urinary bladder i.e., both cystoscopic and cystectomy samples were included in the study. Hematoxylin and eosin-stained slides were re-evaluated whenever required.

Results: A total of 145 cases were included which consisted of 17 cystectomy specimens and 128 cystoscopic biopsies. There was a male predominance. The non-neoplastic and neoplastic cases consisted of 32% and 68% respectively. Chronic non-specific cystitis and high-grade infiltrating urothelial carcinoma were the most common non-neoplastic and neoplastic lesions respectively. 56.1% of cystoscopic biopsies had the presence of detrusor muscle with 21.7% showing its invasion.

Conclusions: Urinary bladder lesions have a wide spectrum ranging from non-neoplastic to neoplastic conditions. The presence of detrusor muscle in a cystoscopic biopsy, and its evaluation for invasion helps in diagnosis and further planning of patient management.

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Author Biographies

Manisha Shrestha, Patan Academy of Health Sciences, Lalitpur, Nepal

Lecturer, Department of Pathology

Dipti Gautam, Patan Academy of Health Sciences, Lalitpur, Nepal

Department of Pathology

Prakriti Shah, Patan Academy of Health Sciences, Lalitpur, Nepal

Department of Pathology

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Published

2021-12-31

How to Cite

Shrestha, M., Gautam, D., Shah, P., & Shrestha, P. K. (2021). Histopathological Spectrum of Non-neoplastic and Neoplastic Lesions of Urinary Bladder. Nepalese Medical Journal, 4(2), 473–477. https://doi.org/10.3126/nmj.v4i2.41353

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Original Articles