Nepalese Medical Journal https://www.nepjol.info/index.php/nmj <p>Nepalese Medical Journal is published by Health Education Agriculture Nepal (<a title="HEAD" href="http://www.head-nepal.org" target="_blank" rel="noopener">HEAD Nepal</a>). The journal&nbsp;is an official peer-reviewed, medical journal which is published bi-annually and and doesn’t charge any fee for submission, processing, and publication. The journal receives original material of interest to the practitioners and scientists in the field of medicine related to the recent developments in Medical Sciences and all articles are Open Access.</p> <p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by/4.0/88x31.png" alt="Creative Commons Licence"></a><br>All articles published in the Journal of Pathology are licensed under a&nbsp;<a href="http://creativecommons.org/licenses/by/4.0/" rel="license">Creative Commons Attribution 4.0 International License</a>.<br>Journal of Pathology of Nepal is indexed on <a title="DOAJ-NMJ" href="https://doaj.org/toc/2645-8586?source=%7B%22query%22%3A%7B%22filtered%22%3A%7B%22filter%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22terms%22%3A%7B%22index.issn.exact%22%3A%5B%222631-2093%22%2C%222645-8586%22%5D%7D%7D%2C%7B%22term%22%3A%7B%22_type%22%3A%22article%22%7D%7D%5D%7D%7D%2C%22query%22%3A%7B%22match_all%22%3A%7B%7D%7D%7D%7D%2C%22from%22%3A0%2C%22size%22%3A100%7D">DOAJ</a></p> en-US <p>Copyright on any article published by Nepalese Medical Journal is retained by the author(s).</p><p>Authors grant Nepalese Medical Journal a license to publish the article and identify itself as the original publisher.</p><p>Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.</p><p><a href="http://creativecommons.org/licenses/by/4.0/" rel="license"><img style="border-width: 0;" src="https://i.creativecommons.org/l/by/4.0/88x31.png" alt="Creative Commons Licence" /></a><br />All articles published in Nepalese Medical Journal  licensed under a <a href="http://creativecommons.org/licenses/by/4.0/" rel="license">Creative Commons Attribution 4.0 International License</a>.</p><p>This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.</p> nepmedj@gmail.com (Dr Shiva Raj KC) scumming@inasp.info (Sioux Cumming) Wed, 01 Apr 2020 00:00:00 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Statin Drug Therapy May Increase Covid-19 Infection https://www.nepjol.info/index.php/nmj/article/view/28256 <p>Enveloped viruses like Coronavirus acquire their envelope from the host cell membrane which is a bilayer of phospholipid interspersed with cholesterol molecules and proteins. Viruses enter their host cell by coming in contact with their specific receptors.&nbsp;Experiments have shown that when cell membranes are depleted of cholesterol in vitro by Methyl beta cyclodextrin (MβCD) these Coronaviruses are not able to enter the host cell membrane by the process of receptor mediated endocytosis.&nbsp;Statin inhibits HMG Co-A reductase, a key enzyme in the Mevalonate pathway resulting into either very low or no production of endogenous cholesterol by the human cells.&nbsp;This results into upregulation of LDL-R in the cell membrane which may lead to more cholesterol getting incorporated into the cell membrane through LDL-C from the plasma creating greater number of lipid rafts suitable for entry of enveloped viruses by receptor-mediated endocytosis.</p> Sanjaya Kumar Shrestha ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 https://www.nepjol.info/index.php/nmj/article/view/28256 Mon, 30 Mar 2020 12:05:13 +0000