Role of Tranexamic acid in NSAIDS induced angioedema

Authors

  • Rupak Chalise Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Saroj Poudel Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Manoj Bist Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Ashim Regmi Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Anup Ghimire Department of Critical Care Medicine, Nepal Mediciti Hospital
  • Kishor Khanal Department of Critical Care Medicine, Nepal Mediciti Hospital

DOI:

https://doi.org/10.3126/nrj.v2i1.59613

Keywords:

Anaphylaxis, Non-allergic Anaphylaxis, Tranexamic acid, Angioedema

Abstract

Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits the conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation. Tranexamic acid is used in the prophylactic management of hereditary angioedema; however, evidence for TXA in Non-Steroidal Anti-inflammatory drug-induced angioedema (NSAIDS-AE) is limited. We describe a patient who presented to the ICU department with NSAIDS-AE and was successfully treated with TXA. This case suggests that TXA may be a beneficial treatment modality in the management of NSAIDS-AE and warrants further investigation.

Downloads

Download data is not yet available.
Abstract
210
PDF
278

Downloads

Published

2023-11-06

How to Cite

Chalise, R., Poudel, S., Bist, M., Regmi, A., Ghimire, A., & Khanal, K. (2023). Role of Tranexamic acid in NSAIDS induced angioedema. Nepalese Respiratory Journal, 2(1), 31–33. https://doi.org/10.3126/nrj.v2i1.59613

Issue

Vol. 2 No. 1 (2023)

Section

Case Reports

License

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.