Intravenous Lipid Emulsion Therapy: A Crucial Approach for Treating Lipophilic Drug Poisoning- A Case Study from Nepal

Abstract

Intravenous lipid emulsion (ILE) therapy has emerged as a promising treatment for lipophilic drug poisoning, particularly in cases where conventional therapies fail. This case study from Nepal highlights the successful use of ILE therapy in treating a severe calcium channel blocker (CCB) overdose. A 37-year-old female patient with an intentional amlodipine overdose presented with bradycardia, hypotension, and metabolic acidosis. Despite initial treatment with high-dose insulin, calcium gluconate, and inotropic support, her condition remained critical. The initiation of ILE therapy led to rapid hemodynamic stabilization, allowing the discontinuation of vasopressors and normalization of metabolic parameters within 24 hours. The patient recovered without adverse effects and was discharged in stable condition. This case underscores the potential of ILE therapy as a life-saving intervention in severe CCB toxicity and highlights the need for further research to optimize its use in clinical practice.