Pattern of Thyroid Dysfunction in Women with Menstrual Disorders

  • Saroj Khatiwada Modern Technical College, Sanepa, Lalitpur http://orcid.org/0000-0002-5158-9324
  • Sharad Gautam Kathmandu University School of Medical Sciences, Dhulikhel http://orcid.org/0000-0002-2040-8543
  • Rajendra KC Modern Technical College, Sanepa, Lalitpur
  • Shruti Singh KIST Medical College and Teaching Hospital, Lalitpur
  • Shrijana Shrestha B P Koirala Institute of Health Sciences, Dharan
  • Punam Jha B P Koirala Institute of Health Sciences, Dharan
  • Nirmal Baral B P Koirala Institute of Health Sciences, Dharan
  • Madhab Lamsal B P Koirala Institute of Health Sciences, Dharan
Keywords: Menstrual disorder, Thyroid dysfunction

Abstract

BACKGROUND
Thyroid disorders are among the commonest endocrine disorders worldwide. Thyroid dysfunction can interfere in multiple metabolic and physiological processes including menstrual cycle. This study was conducted to find pattern of thyroid dysfunction among women with menstrual disorders.

METHODS
Two hundred thirty three females with menstrual disorders were screened for thyroid dysfunction. Thyroid function was assessed by measuring serum free triiodothyronine (T3), free thyroxine (T4) and thyroid stimulating hormone (TSH) levels.

RESULTS
The mean age of study patients was 25.7±6.8 years. The most common menstrual disorder observed was irregular cycle (72.5%, n=169) followed by amenorrhea (21.9%, n=51) and menorrhagia (5.6%, n=13). Most of the patients were in the age group 15-24 years (51.1%, n=119), followed by 25-34 years (36.1%, n=84) and 35-45 years (12.9%, n=30). Mean level of free T3 and T4 was 2.91±1.05 pg/ml, 1.42±0.57 ng/dl respectively. Median TSH was 2.0 mIU/L (IQR, 1.0-4.0). Thyroid dysfunction was seen in 25.8% (n=60) women. Most common thyroid dysfunction was subclinical hypothyroidism (14.2%, n=33) followed by subclinical hyperthyroidism (6.9%, n=16), overt hyperthyroidism (3%, n=7) and overt hypothyroidism (1.7%, n=4).

CONCLUSIONS
The study finds thyroid dysfunction especially subclinical hypothyroidism to be common among women with menstrual disorders. Thus, it may be beneficial to screen menstrual disorder patients for thyroid function especially to rule out thyroid disorder as potential etiological agent for menstrual disturbance.

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Author Biographies

Saroj Khatiwada, Modern Technical College, Sanepa, Lalitpur
Department of Biochemistry
Sharad Gautam, Kathmandu University School of Medical Sciences, Dhulikhel

Lecturer

Department of Biochemistry

Rajendra KC, Modern Technical College, Sanepa, Lalitpur

Department of Biochemistry

Shruti Singh, KIST Medical College and Teaching Hospital, Lalitpur

Department of Biochemistry

Shrijana Shrestha, B P Koirala Institute of Health Sciences, Dharan
Assistant Professor

Department of Biochemistry

Punam Jha, B P Koirala Institute of Health Sciences, Dharan

Assistant Professor,

Department of Biochemistry

Nirmal Baral, B P Koirala Institute of Health Sciences, Dharan

Department of Biochemistry

Madhab Lamsal, B P Koirala Institute of Health Sciences, Dharan

Department of Biochemistry

Published
2016-05-03
How to Cite
Khatiwada, S., Gautam, S., KC, R., Singh, S., Shrestha, S., Jha, P., Baral, N., & Lamsal, M. (2016). Pattern of Thyroid Dysfunction in Women with Menstrual Disorders. Annals of Clinical Chemistry and Laboratory Medicine, 2(1), 3-6. https://doi.org/10.3126/acclm.v2i1.14195
Section
Original Articles