Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy

Authors

  • Anil Singh Basnyat Department of Biotechnology, Kathmandu University
  • Prabin Prabin Gyawali Kathmandu University, School of Medical Sciences
  • Abimanyu Jha Institute of Medicine, Maharajgunj Medical Campus, Tribhuwan Univeristy Teaching Hospital
  • Prabodh Risal Kathmandu University, School of Medical Sciences
  • Bhupal Govinda Shrestha School of Science Kathmandu University

DOI:

https://doi.org/10.3126/acclm.v2i2.15589

Keywords:

Breast cancer, chemotherapy, C-peptide, lipid profile.

Abstract

Background: Chemotherapy agents alter serum lipids and C-peptide in cancer patients increased incidence of cardiovascular disorders and diabetes, although mechanisms for these are not known. Diabetes and cardiovascular riskis the highly concerned chemotherapy induced complications among cancer patients. This study is aimed to evaluate the serum lipids and C-peptide in breast cancer patients receiving chemotherapy.

Methods: This cross-sectional study includes160 individuals comprising 80 breast cancer patients and 80 controls with age ranges from 24 to 76 years. Patients received at least 3 cycles of chemotherapy. Serum Total cholesterol (TC), high density lipoprotein cholesterol (HDL) andC-peptide level was measuredin random blood sampleswhereas,other lipid parameters like Non HDL (TC-HDL),cardiac risk ratio (TC: HDL) and Non-HDL: HDL werecalculated.

Results: SerumTC, Non-HDL, TC: HDL, Non-HDL: HDL and C-peptide were significantly increased in breast cancer patients as compared to control group (p<0.001). HDL cholesterol level inpremenopausal and postmenopausalpatients was decreased but was not statistically significant different.

Conclusions: Altered serum lipid parameters and C-peptide indicated the risk of cardiovascular diseases and diabetes in cancer patients. Routine assessments of these parameters are necessary for follow up care during breast cancer management.

Clin. Chem. Lab. Med. 2016:2(2); 8-14

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Author Biographies

Prabin Prabin Gyawali, Kathmandu University, School of Medical Sciences

Department of Biochemistry

Abimanyu Jha, Institute of Medicine, Maharajgunj Medical Campus, Tribhuwan Univeristy Teaching Hospital

Department of Pathology

Prabodh Risal, Kathmandu University, School of Medical Sciences

Department of Biochemistry

Bhupal Govinda Shrestha, School of Science Kathmandu University

Department of Biotechnology

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Published

2017-03-31

How to Cite

Basnyat, A. S., Prabin Gyawali, P., Jha, A., Risal, P., & Shrestha, B. G. (2017). Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy. Annals of Clinical Chemistry and Laboratory Medicine, 2(2), 8–14. https://doi.org/10.3126/acclm.v2i2.15589

Issue

Vol. 2 No. 2 (2016)

Section

Original Articles

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