Is either arterial or venous antithrombin III level linked to outcome in elderly males versus females with severe sepsis?

Authors

  • Nermien N Adly Lecturer of Geriatric Medicine, Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo
  • Rania M Abou-Hashema Lecturer of Geriatric Medicine, Geriatrics and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo

DOI:

https://doi.org/10.3126/ajms.v6i1.10795

Keywords:

Severe sepsis, Gender, Antithrombin III, Outcome, SOFA, Elderly, Egypt

Abstract

Objectives: We aimed to study arterial and venous ATIII levels, in elderly males and females with severe sepsis, and their impact upon the patients’ outcomes.

Patients and Methods: A cohort study was performed in thirty-nine elderly patients with severe sepsis. Arterial and venous ATIII levels were measured. Sequential Organ Failure Assessment (SOFA) score was calculated.

 Results: Both arterial and venous ATIII levels were negatively correlated with age in the whole sample (P=0.004 and .05 consecutively) (r = −0.45 and −0.32 consecutively). There was a significant difference between the arterial and venous ATIII levels in males (P=0.04). In males, SOFA score was positively correlated with arterial ATIII and the difference between arterial and venous ATIII levels (P=0.04 and .05 consecutively). Arterial and venous ATIII were the significant predictors of SOFA score, only in males (P <0.001 and 0.003 consecutively).

Conclusion: ATIII level decreased with increasing age. In males, both higher arterial and lower venous ATIII levels were significant predictors of worse organ dysfunction.

DOI: http://dx.doi.org/10.3126/ajms.v6i1.10795

Asian Journal of Medical Sciences Vol.6(1) 2015 34-39

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Published

2014-07-24

How to Cite

Adly, N. N., & Abou-Hashema, R. M. (2014). Is either arterial or venous antithrombin III level linked to outcome in elderly males versus females with severe sepsis?. Asian Journal of Medical Sciences, 6(1), 34–39. https://doi.org/10.3126/ajms.v6i1.10795

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Section

Original Articles