Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

Authors

  • Muhammed Saleh Najdat Medical doctor, Specialist of Internal Medicine M.D., Fellow of Iraqi Board of Medical Specialties Member of Royal College of Physicians (United Kingdom) Faculty of Internal Medicine, Baghdad Medical City Teaching Complex, Baghdad
  • Ahmed M Lutfi Medical doctor, Anatomist, and Dermatologist MD, PG-Cert (United States), PG-Diploma (United Kingdom), M.Sc. (United Kingdom) Member of European Academy of Dermatology and Venereology (EADV) Member of National Academy of Neuropsychology (NAN) Member of American Association of Anatomists (AAA) Department of Pathology and Forensic Medicine, College of Medicine, Baghdad University http://orcid.org/0000-0003-1846-9424

DOI:

https://doi.org/10.3126/ajms.v7i3.13880

Keywords:

High-sensitivity C-reactive protein, Asthma, Obstructive, Corticosteroids, Inflammation, Iraq.

Abstract

Aims and Objectives: To evaluate the relevance of high-sensitivity assays for C-reactive protein (hs-CRP), as a sensitive marker of inflammation in asthmatic Iraqi patients. Additionally, correlations of serum levels of hs-CRP with patients’ clinical characteristics and pulmonary function tests (PFTs) will be studied in a cross-sectional design.

Materials and Methods: A random sample of 58 individuals were divided into a healthy (control) group (n = 12) and two groups of adult patients with chronic stable asthma; (n = 22) patients had been receiving inhaled corticosteroids (inhaled corticosteroid-positive, or ICS+VE, group) for the past 2–3 months, and (n = 24) steroid-naive patients (inhaled corticosteroid-negative, or ICS-VE, group). The selected individuals were subjected to hs-CRP measurement and PFTs.

Results: The forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), was measured in all subjects. In the ICS+VE and the ICS-VE groups, there was a significant correlation between the level of hs-CRP and FEV1/FVC with r: ?0.891 and a p-value of < 0.0005 for both groups. In the ICS-VE group, 78.5% had significant clinical symptoms, whereas only 22.7% of the ICS+VE group had significant clinical symptoms. This difference (for the prevalence of clinical symptoms) was significant with a chi-square value of 19.59, degree of freedom (df) = 1, and p < 0.0005.

Conclusion: In the ICS-VE group, the level of hs-CRP was significantly higher than in both the ICS+VE group and the control group. The values of the PFTs were significantly lower in the ICS-VE group. The prevalence of clinical features was significantly higher in the ICS-VE group.

Asian Journal of Medical Sciences Vol. 7(3) 2016 47-53

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Published

2016-01-06

How to Cite

Najdat, M. S., & Lutfi, A. M. (2016). Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests. Asian Journal of Medical Sciences, 7(3), 47–53. https://doi.org/10.3126/ajms.v7i3.13880

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Original Articles