Genetic Variation and Population structure: A study on four populations of Tripura, North East India

Authors

  • Priyanka Das Research Student, Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal
  • Pranabesh Sarkar Senior Research Fellow (UGC-NET), Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal
  • Diptendu Chatterjee Assistant Professor, Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal
  • Arup Ratan Bandyopadhyay Professor, Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal http://orcid.org/0000-0003-3119-0022

DOI:

https://doi.org/10.3126/ajms.v9i3.19492

Keywords:

ABO, RhD, HP, Tripura, Fst, Genetic difference

Abstract

Back Ground: Genetic polymorphisms of ABO and RhD blood group and Haptoglobin (HP) types have already been widely used to understand variation and population structure. The present study attempted to understand the variation and population structure on the basis of ABO and RhD blood group polymorphisms and Haptoglobin (HP) as serum protein polymorphism of four Tibeto-Burman speaker groups considered as aboriginal tribes of Tripura. Genetic studies on populations in north-east Indian have been performed less frequently than in the other parts of India, in spite of diversity among these populations.

Aims and Objective: Best of the knowledge the present study is the first attempt on the variation and population genetic structure concerning the ABO, RhD and HP polymorphism of the four endogamous populations – Tripuri, Hrangkhawl, Rupini and Kolui tribal population of Tripura.

Materials and Methods: Present study consisted of four hundred (400) participants 100 each from above mentioned population groups. ABO and RhD blood groups were done by antigen-antisera agglutination test and HP types were ascertained by Polyacrylamide Gel Electrophoresis (PAGE) following standard techniques. Allele frequencies and Fst were calculated by using standard method.

Results: Examination on ABO blood group revealed higher O allele among the two groups Tripuri and Hrangkhawl followed by A and B alleles. Among the other two groups, Rupini and Kolui, revealed higher A allele and B allele respectively. Higher D allele frequency in the RHD Blood group system has been found for each of the population group. On the other hand, Serum protein marker - HP types demonstrated higher HP*2 allele frequency than HP*1 alleles. Calculated very low Fst value (0.02-0.08) of three polymorphic markers (ABO, RhD and HP) were suggestive for low differentiation among these groups, indicating less admixture and prevailing endogamous nature of these population.

Conclusion: Very low Fst values of three polymorphic markers were suggestive for low differentiation among these groups, indicating least admixture and prevailing endogamous nature of these population. The overall genetic difference revealed highest distance between Tripuri and Hrangkhwal and least distance between Rupini and Kolui.

Asian Journal of Medical Sciences Vol.9(3) 2018 46-49

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Author Biographies

Priyanka Das, Research Student, Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal


 

Pranabesh Sarkar, Senior Research Fellow (UGC-NET), Department of Anthropology, University of Calcutta, Technology & Agriculture, 35, Ballygunge Circular Road, Kolkata – 700019, West Bengal


 

 

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Published

2018-05-01

How to Cite

Das, P., Sarkar, P., Chatterjee, D., & Bandyopadhyay, A. R. (2018). Genetic Variation and Population structure: A study on four populations of Tripura, North East India. Asian Journal of Medical Sciences, 9(3), 46–49. https://doi.org/10.3126/ajms.v9i3.19492

Issue

Vol. 9 No. 3 (2018)

Section

Short Communications

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