Association of Autonomic imbalance with Parental history of Type 2 Diabetes Mellitus
Keywords:Autonomic dysfunction, Heart rate recovery, Parental history, Type 2 Diabetes mellitus
Background: Off springs with a parental history of type 2 diabetes mellitus are genetically susceptible to develop diabetes. In some recent reports it has been shown that these vulnerable population exhibit altered autonomic activity even before the manifestations of disease. Autonomic dysfunction might be the initial cardiac pathology in subclinical type2 diabetes. Till now very few studies have been done to find out the early outcomes of this genetic transmission. Keeping in view of the above facts, the current study was carried out to find out the association between autonomic dysfunction and parental history of diabetes.
Aim and Objectives: This study was aimed to quantify and compare the difference (if any) of heart rate recovery in response to 3minute step test between the young non diabetic children of non-diabetic and diabetic parents.
Materials and Methods: Fifty-one non diabetic students were divided into two groups. One group comprised of students with parental history of type2 diabetes mellitus and another group with students without parental history of diabetes. Each student was subjected to 3minute Master step test. Recordings of heart rate were made before and after exercise. Heart arte recovery (HRR) in 1 minute (HRR1) as well as in 2, 3 and 4 minute (HRR2,HRR3, HRR4) were recorded and analyzed.
Results: The resting (basal) as well as 1stminute heart rate recovery (HRR1) was not significantly different between the two groups. Likewise, the 2nd minute HRR (HRR2), 3rd minute HRR (HRR3) and 4th minute HRR (HRR4) respectively were also not significantly different between the two groups.
Conclusion: This study concludes that there is no difference in the heart rate recovery in response to the exercise stress test between the young non diabetic children of non-diabetic and diabetic parents. Therefore, parental history of diabetes does not have any impact on the cardiovascular autonomic activity before the disease manifestation.
How to Cite
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).