Effect of intraoperative use of dexmedetomidine on post-operative analgesia in patients undergoing elective spine surgery under general anaesthesia

Authors

  • Madhumita Ray Associate Professor, Department Of Anaesthesiology, College Of Medicine and JNM Hospital, WBUHS, ,Kalyani, Nadia, West Bengal, India https://orcid.org/0000-0002-2882-5405
  • Chanchal Kumar Dalai Associate Professor, Department Of Pharmacology, College Of Medicine and JNM Hospital, WBUHS, ,Kalyani, Nadia, West Bengal, India https://orcid.org/0000-0002-5406-3440
  • Shah Newaz Ahmed Demonstrator, Department Of Pharmacology, College Of Medicine and JNM Hospital, WBUHS, ,Kalyani, Nadia, West Bengal, India https://orcid.org/0000-0003-0083-346X
  • Amita Acharjee Professor and Head Of The Department, Department Of Neuro-anaesthesiology, Bangur Institute of Neurosciences, Kolkata , West Bengal, India

DOI:

https://doi.org/10.3126/ajms.v12i5.34151

Keywords:

Dexmedetomidine, General anaesthesia, Analgesia, Spine surgery

Abstract

Background: Dexmedetomidine is an alpha2 agonist which shows sedative, analgesic and anti-adrenergic effects and is useful as an adjuvant agent in general anaesthesia (GA) in major surgeries.

Aims and Objectives: In this study, we evaluated the analgesic efficacy of intra-operative infusion of dexmedetomidine in alleviating post-operative pain in elective spine surgery using multiple efficacy parameters.

Materials and Methods: Patients (n=60) scheduled to undergo elective spine surgery under GA were randomised to receive either dexmedetomidine (treatment arm) or normal saline (control arm) in the intra-operative period. The analgesic efficacy of the drug in the post-operative period was assessed using- the time to first rescue analgesic, total requirement of analgesic, Visual Analog Scale (VAS) score and the number of back-up analgesic required.

Results: There was no statistically significant difference in the baseline clinical and demographic characteristics between the two groups. The time to first rescue analgesic, total requirement of analgesic, Visual Analog Scale (VAS) score and the number of back-up analgesic required, were all statistically significant in favour of the treatment arm (P<0.001).

Conclusion: Dexmedetomidine provides effective postoperative analgesia and reduces tramadol requirements in elective spine surgery performed under general anaesthesia.

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Published

2021-05-01

How to Cite

Ray, M., Dalai, C. K., Ahmed, S. N., & Acharjee, A. (2021). Effect of intraoperative use of dexmedetomidine on post-operative analgesia in patients undergoing elective spine surgery under general anaesthesia. Asian Journal of Medical Sciences, 12(5), 88–93. https://doi.org/10.3126/ajms.v12i5.34151

Issue

Vol. 12 No. 5 (2021)

Section

Original Articles

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