Comparison between esmolol and verapamil in attenuation of cardiovascular stress response to laryngoscopy and endotracheal intubation in elective surgery

Authors

  • Nitisha Chakraborty Senior Resident, Department of Anesthesiology, Critical Care & Pain, R.G. Kar Medical College & Hospital, Kolkata, West Bengal, India
  • Sankar Roy Associate Professor, Department of Anesthesiology, R.G. Kar Medical College & Hospital, Kolkata, West Bengal, India
  • Debajyoti Sur Assistant Professor, Department of Anesthesiology, R.G. Kar Medical College & Hospital, Kolkata, West Bengal, India
  • Arunava Biswas Associate Professor, Department of Pharmacology, Maharaja Jitendra Narayan Medical College & Hospital, Coochbehar, West Bengal, India https://orcid.org/0000-0002-9676-3410
  • Dipasri Bhattacharya Professor, Department of Anesthesiology, R.G. Kar Medical College & Hospital, Kolkata, West Bengal, India
  • Anjan Adhikari Professor, Department of Pharmacology, Maharaja Jitendra Narayan Medical College & Hospital, Coochbehar, West Bengal, India

DOI:

https://doi.org/10.3126/ajms.v12i7.35759

Keywords:

Esmolol, Verapamil, Cardiovascular stress, Laryngoscopy, Endotracheal intubation

Abstract

Background: Cardiovascular stress due to reflex sympathetic over activity is a great concern during laryngoscopy and endotracheal intubation.

Aims and Objectives: To compare the efficacy and safety of esmolol and verapamil for attenuation of hemodynamic effects (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) due to laryngoscopy and endotracheal intubation in elective surgical cases.

Materials and Methods: A prospective, randomized, double blinded, controlled study was conducted on 60 patients divided equally into 30 each receiving esmolol (2 mg/kg body weight) and verapamil (0.1 mg/kg body weight) respectively. Heart rate, systolic and diastolic blood pressure and mean arterial pressure were recordedat pre-operative stage, after administration of the study drugs, immediately after intubation and at 1 ,3 ,5 minutes after intubation. Data collected were statistically analyzed.

Results: The mean systolic blood pressure was lower in the esmolol group at all times of estimation compared with the verapamil group and the difference was at the time of intubation (p value <0.001).The mean diastolic blood pressure was lower in the esmolol group at all times of estimation compared to the verapamil group which was not statistically significant at any time of estimation. The mean arterial pressure was significantly lower at the time of immediately after intubation (p<0.001) in esmolol as compared to verapamil group. Adverse effects in both the study groups were insignificant.

Conclusion: Esmololand Verapamil can effectively attenuate the cardiovascular stress to laryngoscopy and endotracheal intubation with the former appears to be a better alternative from efficacy and safety perspectives.

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Published

2021-07-01

How to Cite

Chakraborty, N., Roy, S., Sur, D., Biswas, A., Bhattacharya, D., & Adhikari, A. (2021). Comparison between esmolol and verapamil in attenuation of cardiovascular stress response to laryngoscopy and endotracheal intubation in elective surgery. Asian Journal of Medical Sciences, 12(7), 64–68. https://doi.org/10.3126/ajms.v12i7.35759

Issue

Vol. 12 No. 7 (2021)

Section

Original Articles

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