Study on coagulation profile in women with pregnancy-induced hypertension in South Indian population

Authors

  • Arjun Shekar Assistant Professor, Department of Physiology, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India https://orcid.org/0000-0001-6494-536X
  • Lokesh Mustoor Raman Associate Professor, Department of General Medicine, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India https://orcid.org/0000-0003-2526-6967
  • Shivakumar Pujari Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India https://orcid.org/0000-0003-0438-5318
  • Prashanthkumar Goudappala Assistant Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India https://orcid.org/0000-0003-3207-7072

DOI:

https://doi.org/10.3126/ajms.v13i12.48624

Keywords:

Coagulation profile; Eclampsia; Preeclampsia; Pregnancy-induced hypertension

Abstract

Background: Pregnancy-induced hypertension (PIH) complicates about 6–10% of pregnancies around the world. According to the WHO, PIH is one of the leading causes of maternal, fetal, and neonatal mortality and morbidity. PIH causes many hematological aberrations in women and any abnormalities in the coagulation of blood lead to hemorrhages.

Aims and Objectives: The objectives of this study were as follows: 1. To study the coagulation profile which includes platelet count, bleeding time (BT), clotting time, prothrombin time, and activated partial thromboplastin time (aPTT) in PIH patients. 2. To compare the above parameters between the normal pregnant subjects and pregnancy-induced hypertensive patients. 3. To compare the above parameters between preeclampsia (PE) and eclampsia patients.

Materials and Methods: A cross-sectional study was conducted on 120 pregnant women. Among them, 60 patients (Cases) who were diagnosed with PIH, and another 60 (controls) having age and anthropometrically-matched healthy pregnant women were taken as control. Their coagulation profile, which includes total platelet count (TPC), prothrombin time (PT), aPTT coagulation time (CT), and BT were studied. The parameters were compared using Student’s t-test.

Results: There was a significantly lower TPC, and increased PT, aPTT, CT, and BT in women with PIH when compared to normal pregnant women. However, there was no significant difference between women with PE and eclampsia.

Conclusion: The present study shows significant changes in coagulation profile in women with PIH.

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Published

2022-12-01

How to Cite

Shekar, A., Mustoor Raman, L. ., Shivakumar Pujari, & Prashanthkumar Goudappala. (2022). Study on coagulation profile in women with pregnancy-induced hypertension in South Indian population. Asian Journal of Medical Sciences, 13(12), 127–130. https://doi.org/10.3126/ajms.v13i12.48624

Issue

Vol. 13 No. 12 (2022)

Section

Original Articles

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Copyright (c) 2022 Asian Journal of Medical Sciences

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