Thermal properties of normal and sickled hemoglobin protein

Jhulan Powrel; Narayan P Adhikari

doi:10.3126/bibechana.v18i1.29750

Thermal properties of normal and sickled hemoglobin protein

Jhulan Powrel Central Department of Physics, Tribhuvan University, Kirtipur
Narayan P Adhikari Central Department of Physics, Kirtipur https://orcid.org/0000-0003-4535-1368

DOI: https://doi.org/10.3126/bibechana.v18i1.29750

Keywords: Thermodynamic properties, Sickle cell, Molecular dynamics, Hemoglobin protein, PDB

Abstract

Thermodynamic properties of sickled and normal hemoglobin protein are considered within the framework of classical molecular dynamics. Here we have studied the specific heat capacity and RMSD (Root Mean Square Deviation) of both types of hemoglobin protein. Our investigation reveals that the specific heat capacity and RMSD for oxygenated hemoglobin protein is higher than those of de-oxygenated sickle hemoglobin protein. It is also observed that the specific heat capacity and RMSD values of sickle hemoglobin protein decrease with a rise in temperature.

BIBECHANA 18 (1) (2021) 140-148

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Published

2021-01-01

How to Cite

Powrel, J., & Adhikari, N. (2021). Thermal properties of normal and sickled hemoglobin protein. BIBECHANA, 18(1), 140-148. https://doi.org/10.3126/bibechana.v18i1.29750

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Issue

Vol 18 No 1 (2021)

Section

Research Article

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