Synthesis of antioxidative anthraquinones as potential anticancer agents

Authors

  • Richa K. Gupta Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur
  • Ganesh M. S. Thakuri Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur
  • Gan B Bajracharya Laboratory of Catalysis and Frontier Molecules, Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur https://orcid.org/0000-0002-3061-6557
  • Ram Narayan Jha Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Ghantaghar, Kathmandu

DOI:

https://doi.org/10.3126/bibechana.v18i2.31234

Keywords:

Acetylation, Antibacterial, Antioxidant, Chrysophanol, Friedel-Crafts Reaction

Abstract

Antioxidant and antibacterial activities of natural anthraquinones namely chrysophanol (1) and emodin (2), and synthesized anthraquinones viz. 2-methylanthraquinone (3), anthraquinone (4), 2-bromoanthraquinone (5), rubiadin (6), chrysophanol diacetate (7), rubiadin diacetate (8) and 1,8-dimethoxy-3-methylanthraquinone (9) were investigated. Anthraquinones 9, 3, 6, 5 and 2 exhibited a high DPPH• radical scavenging capacity (IC50 = <500 μg/mL) showing their therapeutic potentiality for the treatment of cancers. These anthraquinones 1-9 have also displayed a weak to moderate antibacterial activity against Bacillus subtilis. Chrysophanol diacetate (7) including emodin (2) have been appeared as the valuable antibacterials.

BIBECHANA 18 (2) (2021) 143-153

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Published

2021-06-09

How to Cite

Gupta, R. K., Thakuri, G. M. S., Bajracharya, G. B., & Jha, R. N. (2021). Synthesis of antioxidative anthraquinones as potential anticancer agents. BIBECHANA, 18(2), 143–153. https://doi.org/10.3126/bibechana.v18i2.31234

Issue

Section

Research Article