Anti-diabetic potential of crude extracts of medicinal plants used as substitutes for <i>Swertia chirayita</i> using <i>in vitro</i> assays

Authors

  • Susanna Phoboo Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst
  • Prasanta C Bhowmik Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst
  • Pramod Kumar Jha Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu
  • Kalidas Shetty Department of Food Science, University of Massachusetts, Amherst

DOI:

https://doi.org/10.3126/botor.v7i0.4373

Keywords:

Andrographis paniculata, antioxidant activity, cinnamates, mangiferin, Swertia nervosa, swertiamarin, ?-glucosidase, type-2 diabetes

Abstract

Swertia chirayita is a highly traded medicinal plant of Nepal widely used for its anti-diabetic potential. In this study, two herbs (Swertia nervosa and Andrographis paniculata) often used as adulterants and substitutes of Swertia chirayita were analyzed for their antioxidant activity, α-glucosidase inhibitory potential and total phenolic content and compared with that of Swertia chirayita. Aqueous and 12% ethanolic extracts of the three herbs showed moderate to high antioxidant activity and moderate α-glucosidase inhibitory potential. HPLC/ DAD revealed the presence of swertiamarin and mangiferin in all the Swertia species, while Andrographis paniculata contained cinnamates such as cinnamic acid, p-coumaric acid and chlorogenic acid. The antioxidant activity and α-glucosidase inhibitory potential was evident in the two herbs indicating their relevance as substitutes for Swertia chirayita for potential early stage management of type-2 diabetes and related complications.

Key-words: Andrographis paniculata; antioxidant activity; cinnamates; mangiferin; Swertia nervosa; swertiamarin; α-glucosidase; type-2 diabetes.

DOI: 10.3126/botor.v7i0.4373

Botanica Orientalis – Journal of Plant Science (2010) 7: 48-55

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How to Cite

Phoboo, S., Bhowmik, P. C., Jha, P. K., & Shetty, K. (2011). Anti-diabetic potential of crude extracts of medicinal plants used as substitutes for <i>Swertia chirayita</i> using <i>in vitro</i> assays. Botanica Orientalis: Journal of Plant Science, 7, 48–55. https://doi.org/10.3126/botor.v7i0.4373

Issue

Vol. 7 (2010)

Section

Research

License

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