Repurposing Artemisia annua L. Flavonoids, Artemisinin and Its Derivatives as Potential Drugs Against Novel Coronavirus (SARS –nCoV) as Revealed by In-Silico Studies

  • Krishna Kumar Rai 1Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
  • - Apoorva Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
  • Lakee Sharma Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
  • Neha Pandey Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
  • Ram Prasad Meena Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
  • Shashi Pandey Rai Laboratory of Morphogenesis, Centre of Advance Study in Botany, Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi-221005 (Uttar Pradesh), India
Keywords: SARS-nCoV, Artemisinin, Artesunate, Remdesvir, in-silico analysis

Abstract

Coronavirus-induced COVID-19, a highly contagious respiratory illness first originated from Wuhan city of Hubei province, China, and has affected 235 countries across the globe. The COVID-19 is mainly transmitted by the droplets of an infected person when they cough, sneeze, or exhale. Currently, there are no specific drugs licensed for the effective treatment or prevention of COVID-19 and the treatment is mainly focused on controlling symptoms. Identification of small bioactive plant molecules that specifically target whole viral replication apparatus have great potential towards the development of antiviral drug discovery. This communication describes our current understanding of SARS-nCoV interaction with some herbal bioactive compounds of A. annua including sesquiterpenes, flavonoids and phenolics using in silico approach.

Int. J. Appl. Sci. Biotechnol. Vol 8(4): 374-393

 

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Published
2020-12-28
How to Cite
Rai, K. K., Apoorva, -, Sharma, L., Pandey, N., Meena, R. P., & Rai, S. P. (2020). Repurposing Artemisia annua L. Flavonoids, Artemisinin and Its Derivatives as Potential Drugs Against Novel Coronavirus (SARS –nCoV) as Revealed by In-Silico Studies. International Journal of Applied Sciences and Biotechnology, 8(4), 374-393. https://doi.org/10.3126/ijasbt.v8i4.33667
Section
Research Articles: Biological Sciences