Anticariogenic Activity and Haemolytic Study of Some Medicinal Plants Leaf Protein Extract against Six Oral pathogens in In vitro condition

  • Hiral Soni Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-3888121, Gujarat
  • Kalpesh Ishnava Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-3888121, Gujarat
  • Khushal Patel Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-3888121, Gujarat
Keywords: Anticariogenic activity, Streblus asper, Candida albicans, haemolytic study

Abstract

Leaf extract of 12 medicinal plants were obtained by using 10mM sodium phosphate buffer and studied for their antibacterial activity against 6 cariogenic pathogens. Among them, the extract from Streblus asper showed the most intensive activity. Antibacterial activity of Streblus asper was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of Streblus asper against Candida albicans causing dental caries was determined to be 2.5 μg/ml. The kinetic study showed that Streblus asper completely inactivated C. albicans at the concentration 50μg/ml in 15hours.Hemolytic study of the Streblus asper plant leaf protein gives HC50 value at a very high range  than that of the MIC values against C. albicans of the organisms and thus flourish its application as successful pharmaceutical drug in practice.

DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.9344

Int J Appl Sci Biotechnol, Vol. 2(3): 253-259  

 

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Abstract
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Published
2014-09-25
How to Cite
Soni, H., Ishnava, K., & Patel, K. (2014). Anticariogenic Activity and Haemolytic Study of Some Medicinal Plants Leaf Protein Extract against Six Oral pathogens in In vitro condition. International Journal of Applied Sciences and Biotechnology, 2(3), 253-259. https://doi.org/10.3126/ijasbt.v2i3.9344
Section
Research Articles