Association of hsCRP and soluble fraction of E-selectin with diabetic and non-diabetic individuals

  • Subinay Datta Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Mrinal Pal Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Amit Kumar Pradhan Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Joydeep Ghosh Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Rajarshi Rahut Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Amrita Ganguly Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
  • Subhadeep Basu Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal
Keywords: Endothelial dysfunction, high sensitive C-reactive protein, soluble E-selectin, Inflammatory marker

Abstract

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Background and aims: It is known that endothelial dysfunction and low-grade inflammation are important element of diabetic complications. The soluble E-selectin is a marker of endothelial dysfunction and C-reactive protein is the most important inflammatory marker. The present study is done to investigate the effect of diabetes on these two markers.

 Methods: The present hospital based case control study was conducted in the department of Biochemistry with the collaboration of department of Medicine of Burdwan Medical College, Burdwan, west Bengal India. All subjects were selected by simple random sampling between March 2011 and May 2013. Blood level of these soluble E-selectin and high sensitive C-reactive protein were measured in two hundred diabetic and two hundred age, sex and other non-modifiable as well as modifiable risk factors matched non-diabetic healthy controls.

Results: Compared with control value of high sensitive C-reactive protein and soluble E-selectin levels were higher in diabetic subjects (p < 0.001). Our present study shows that levels of adhesion molecules and high sensitive C-reactive protein were higher in diabetic than non-diabetic.

Conclusion: These data suggested that an increased level of inflammatory markers and adhesion molecules among diabetic compared with non-diabetic subjects. This suggests that chronic uncontrolled hyperglycemia contributes to progression of atherosclerosis associated with life-threading complications in middle-aged diabetic patients.

DOI: http://dx.doi.org/10.3126/jaim.v3i1.10697

Journal of Advances in Internal Medicine 2014;03(01):17-22

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Abstract
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Published
2014-07-03
How to Cite
Datta, S., Pal, M., Pradhan, A., Ghosh, J., Rahut, R., Ganguly, A., & Basu, S. (2014). Association of hsCRP and soluble fraction of E-selectin with diabetic and non-diabetic individuals. Journal of Advances in Internal Medicine, 3(1), 17-22. https://doi.org/10.3126/jaim.v3i1.10697
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Original Articles