Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance
Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.
Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.
Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P<0.05), but not with the patient age, lymph node metastasis and tumor size (P>0.05).
Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.
Copyright (c) 2017 Xing Zhao, Rajina Sahi, Yu-Yang Zhao, Jun Wang, Chun-Hui Li
This work is licensed under a Creative Commons Attribution 4.0 International License.