Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance

  • Xing Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Rajina Sahi B. P. Koirala Memorial Cancer Hospital
  • Yu-Yang Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Jun Wang Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Chun-Hui Li Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
Keywords: Esophageal carcinoma, HPV 16-E6, Immunohistochemistry

Abstract

Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.

Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P<0.05), but not with the patient age, lymph node metastasis and tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.  

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Abstract
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Published
2017-03-05
How to Cite
Zhao, X., Sahi, R., Zhao, Y.-Y., Wang, J., & Li, C.-H. (2017). Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance. Journal of Advances in Internal Medicine, 4(2), 57-60. https://doi.org/10.3126/jaim.v4i2.16897
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Original Articles