Profile of breakthrough infection of COVID-19 in a tertiary care hospital: a descriptive cross-sectional study

Authors

  • Khilasa Pokharel
  • Bishwa Raj Dawadi
  • Binod Aryal
  • Lok Bahadur Shrestha

Keywords:

Breakthrough; COVID-19; Vaccines.

Abstract

Background: While reports of vaccine induced immunity against COVID-19 have been around, frequency of breakthrough infections is also being reported. The study aimed to analyze breakthrough infections after a complete dose of COVID-19 vaccination.

Methods: Individual who was fully vaccinated with COVID-19 were included in this study. Nasopharyngeal and Oropharyngeal swab was collected and transported to the laboratory as soon as possible for the diagnosis of COVID-19. The specimens were transported in a viral transport medium maintaining cold chain of 2-8°C. Statistical Package for the Social Sciences (SPSS) version 20 was used for data entry and analysis.

Results: Of 8350 samples received 5494 (65.79%) were vaccinated and 2856 (34.20%) were non vaccinated. Among fully vaccinated individuals, 694 (12.63%) are post vaccination COVID-19 cases. Among the post vaccinated COVID-19 cases 264(14.15%), 95(12.70%), 44(3.19%), 28 (1.86%) breakthrough infections are seen among individuals who received Sinopharm, Oxford-Astrazeneca, Johnson and Johnson, other vaccines Pfizer, Moderna, Sputnik V respectively which were tested positive for SARS-CoV-2 RNA on reverse transcriptase polymerase chain reaction.

Conclusions: Laboratory-confirmed COVID-19 cases among vaccinated individuals after complete dose of vaccination indicates that there is still risk of COVID-19. Therefore, regular COVID-19 testing should be conducted even after vaccination.

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Published

2022-03-15

How to Cite

Pokharel, K., Dawadi, B. R., Aryal, B., & Shrestha, L. B. (2022). Profile of breakthrough infection of COVID-19 in a tertiary care hospital: a descriptive cross-sectional study. Journal of Chitwan Medical College, 12(1), 62–64. Retrieved from https://www.nepjol.info/index.php/JCMC/article/view/43827

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Section

Original Research Articles