SERUM LIPID PROFILE AMONG POST-MENOPAUSAL WOMEN ATTENDING TERTIARY HOSPITAL AT CHITWAN, NEPAL

Authors

  • Fuleshwar Mandal Chitwan Medical College
  • Resha Rijal Chitwan Medical College
  • Deepak Kafle Department of Biochemistry, chitwan Medial College
  • Kishor Adhikari School of Public Health and Dept. of Community Medicine, Chitwan Medical College

Keywords:

Cardiovascular disease, Estrogen, Lipid profile, Post-Menopause

Abstract

Background: Menopause is a phase of woman’s natural aging process and is marked by the cessation of ovarian function. The increased incidence of cardiovascular risk in post-menopausal women may be due to hormonal imbalance leading to derangement of lipid profile. The aim of study was to study the serum lipid profile among post-menopausal women attending at a tertiary care hospital in Nepal.

Methods: This was a hospital based descriptive cross-sectional study carried out among 156 post-menopausal women attending Medicine Out Patient Department at Chitwan medical college and teaching hospital. Serum Lipid profile were measured by an automated on Dimension® clinical chemistry analyzer and serum estrogen was measured by CLIA on Siemen ADVIA Centaur XP immunoassay. Data were analyzed using SPSS version 20.

Results: Study finding suggests that serum Triglycerides, Total cholesterol, and LDL were found to be elevated in 48.7%, 23.7% and 14.7% study participants respectively while serum HDL level was found to be low in 10.9% study subjects. Serum HDL had significantly associated with different age groups and estrogen(p<0.05). The serum TG, TC, and LDL were negatively correlated (r = -0.096, p = 0.23), (r = -0.09, p = 0.22), (r = -0.18, p = 0.04) with estrogen respectively while serum HDL was positively correlated (r = 0.32, p = 0.01) with estrogen. The serum TG, TC, LDL were negatively correlated with age and serum HDL was positively correlated with age.

Conclusions: Due to changes in lipid profiles and the loss of estrogen’s cardio preventive impact, post-menopausal women are at an increased risk of developing cardiovascular disease.

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Published

2022-09-05

How to Cite

Mandal , . F. ., Rijal , . R. ., Kafle , . D. ., & Adhikari , . K. . (2022). SERUM LIPID PROFILE AMONG POST-MENOPAUSAL WOMEN ATTENDING TERTIARY HOSPITAL AT CHITWAN, NEPAL . Journal of Chitwan Medical College, 12(2), 118–121. Retrieved from https://www.nepjol.info/index.php/JCMC/article/view/48099

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Section

Original Research Articles