Synthesis, Characterization and Antibacterial Studies of (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-Cr (III) Complex

  • Ifeanyi Edozie Otuokere Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State
  • Unwanaobong Friday Robert Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State
Keywords: Benzylpenicillin, spectroscopic, bacteria, complex, ligand

Abstract

Benzylpenicillin, also known as (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic, is a common bactericidal antibiotic of the betalactamin family which is mostly used to treat infections caused by gram-positive bacterial strains and few gram-negative bacterial strains. Cr (III) complex of benzylpenicillin was synthesized by the reaction of benzylpenicillin with CrCl3.6H2O. The structure of the complex was confirmed through elemental analysis, electrical conductivity, FT-IR, electronic spectra, 1H-NMR, and 13C-NMR spectroscopic methods. The physical properties such as solubility, color and melting point were also determined for both the ligand and the complex. The complex has a deep green color. Both the ligand and the complex are ionic (236.0 and 126.0 Sm2.mol-1). From the spectroscopic result, the ligand behaved as a pentadentate ligand coordinating to the metal ion through OH, NH, C=O of amide, carboxylate& β-lactam. A trigonal bipyramidal geometry has been proposed for the metal complex. The prepared complex was evaluated in vitro for its antibacterial activity against some pathogenic gram-positive (Staphylococcus aureus, Bacillus substilis, Bacillus cereus, and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli, Enterobacter cloacae, Pneumonia aeruginosa and Campylobacter fetus). The metal complex showed enhanced antibacterial activity as compared to the uncomplexed ligand.

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Author Biographies

Ifeanyi Edozie Otuokere, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State

Department of Chemistry

Unwanaobong Friday Robert, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267 Umuahia, Abia State

Department of Chemistry

Published
2020-07-29
How to Cite
Otuokere, I., & Robert, U. (2020). Synthesis, Characterization and Antibacterial Studies of (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-Cr (III) Complex. Journal of Nepal Chemical Society, 41(1), 1-7. https://doi.org/10.3126/jncs.v41i1.30370
Section
Articles