Synthesis, Characterization and Antimicrobial Evaluation of Mannich Bases of 4-(Furan-2-yl-methyleneamino)-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5-thione

Authors

  • Prem Shankar Deo Department of Chemistry, Amrit Science Campus, Tribhuvan University, Kathmandu
  • Rhambus Rawat Department of Chemistry, Amrit Science Campus, Tribhuvan University, Kathmandu
  • Bhushan Shakya Department of Chemistry, Amrit Science Campus, Tribhuvan University, Kathmandu

DOI:

https://doi.org/10.3126/jncs.v42i1.35322

Keywords:

1,2,4-triazole-5-thione, Schiff base, Mannich base, antibacterial activity, antifungal activity

Abstract

Triazole nucleus has drawn much attention since the last decade because of its various potent biological activities. The pharmacological application of triazoles has been widely recognized and well documented. Schiff and Mannich bases are both considered as bioactive compounds, however, there are not much of documentation about the Mannich bases as their study has begun lately. The main aim of this study was to synthesize new Mannich bases from Schiff base bearing 1,2,4-triazole nucleus to access their antimicrobial activities. The newly synthesized compounds 1,2,4-triazole-5-thione, Schiff base (4) and Mannich bases (5a & 5b) were characterized by spectral techniques like UV, FT-IR, and NMR. Mannich bases were tested against various bacterial (gm +ve and gm –ve) as well as fungal strains. The synthesized Mannich bases showed good to moderate activities against the tested bacterial and fungal strains.

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Published

2021-03-01

How to Cite

Deo, P. S., Rawat, R., & Shakya, B. (2021). Synthesis, Characterization and Antimicrobial Evaluation of Mannich Bases of 4-(Furan-2-yl-methyleneamino)-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5-thione. Journal of Nepal Chemical Society, 42(1), 6–15. https://doi.org/10.3126/jncs.v42i1.35322

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Section

Research Article