An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Authors

  • Netra Lal Bhandari Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Sunita Bista Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Tika Ram Gautam Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Kabita Bist Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Ganesh Bhandari Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Sumita Subedi Department of Chemistry and Chemical Engineering, Inha University, Incheon
  • Kedar Nath Dhakal Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu

DOI:

https://doi.org/10.3126/jncs.v42i1.35333

Keywords:

Hydroxyapatite, wet chemical methods, biogenic sources, biomedical applications

Abstract

Hydroxyapatite (HAp) is the mineral phase of animal bones embedded in a collagen-containing organic matrix. It is a naturally optimized material for the physical support of the bones. Synthetic Hydroxyapatite based biomaterials, hence, find wide applications in orthopedics, dentistry, and tissue engineering due to their biocompatibility, bioactivity, osteoconductivity, and similar chemical composition to that of HAp present in animal bones. Different physicochemical synthetic methods and natural biogenic sources have been reported for the synthesis of nano-hydroxyapatite. However, particle size, aspect ratio, and the distribution of HAp in biomaterials have significant effects to use as bone substitutes and implants. This paper has summarized some synthetic methods of preparing nano-HAp from different biogenic approaches. Further, it focuses on some facile synthetic routes of preparing nano-HAp with controlled particle size with higher crystallinity and native bone architectures. This review article aims to correlate some simplistic and cost-effective biosynthetic approaches of nano-HAp, their size-dependent properties characterization, and biomedical applications.

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Published

2021-03-01

How to Cite

Bhandari, N. L., Bista, S., Gautam, T. R., Bist, K., Bhandari, G., Subedi, S., & Dhakal, K. N. (2021). An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials. Journal of Nepal Chemical Society, 42(1), 64–74. https://doi.org/10.3126/jncs.v42i1.35333

Issue

Section

Review Article