Synthesis, Characterization and Biological Screening of Azepine Derivative: 2-hydroxy-1,3-di(naphthalene-2-yl)-1H-benzo[b]azepine-5(4H)one

Authors

  • Amit Sharma Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu
  • Ashok Kumar Singh Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu

DOI:

https://doi.org/10.3126/jncs.v42i1.35336

Keywords:

Azepine derivatives, heterocyclic, pharmacological, antibacterial, antifungal

Abstract

The synthesis of unsaturated heterocyclic compounds containing nitrogen atoms in the ring is very important due to its various biological application in the pharmaceutical industry. Azepine derivatives find numerous application almost every field in medicinal chemistry and some of its are commercially available as drugs. The two-component of azepine derivatives were synthesized by using the aniline and maleic anhydride as a starting material followed by condensation with sodium borohydride in presence of dry benzene, subsequently cyclization by polyphosphoric acid then, finally by an addition reaction with naphthalene-2-ol to form the desired derivative. The formation of the synthesized azepine derivative was confirmed by spectral techniques such as IR, 1H-NMR, and 13C-NMR. The antibacterial assay shows that the synthesized compound (2A) possesses the most highly potent activity in the Bacillus subtilis and moderate activity against other different strains of bacteria and fungi.

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Published

2021-03-01

How to Cite

Sharma, A., & Singh, A. K. (2021). Synthesis, Characterization and Biological Screening of Azepine Derivative: 2-hydroxy-1,3-di(naphthalene-2-yl)-1H-benzo[b]azepine-5(4H)one. Journal of Nepal Chemical Society, 42(1), 75–79. https://doi.org/10.3126/jncs.v42i1.35336

Issue

Section

Research Article