Cytotoxicity of Compounds Isolated from Usnea aciculifera

Authors

  • Sajan L Shyaula Faculty of Science, Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal
  • Teresa Shah Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, Nepal
  • Rajitha Kalum Rathnayaka Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Srilanka
  • Sameera R Samarakoon Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Srilanka
  • Erendra Manandhar Department of Chemistry, Berea college, 101 Chestnut Street, Berea KY, 40404, USA
  • Jian Min Yue Department of Natural Products Chemistry, Shanghai Institute of Materia Medica 555 Zu Chong Zhi Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China
  • Mangala Devi Manandhar Faculty of Science, Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal

DOI:

https://doi.org/10.3126/jncs.v43i2.53357

Keywords:

Usnea aciculifera, LN-229 glioblastoma cancer cell, Sulforhodamine B assay, Atranorin, Usnic acid, D-Arabinitol

Abstract

Atranorin 1, Usnic acid 2, and D-Arabinitol 3 were isolated from Usnea aciculifera by extensive column chromatography. The structures were elucidated based on the comprehensive spectral analysis including FT IR, GC MS, ESI MS, 13C NMR, and 1H NMR. The compounds were evaluated for their cytotoxic activity against LN-229 glioblastoma cancer cell line by performing Sulforhodamine B assay (SRB). Usnic acid 2 showed strong cytotoxic activity against LN-229 glioblastoma cancer cell with an IC50 value of 3.09 μg/mL.

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Published

2023-04-25

How to Cite

Shyaula, S. L., Shah, T., Rathnayaka, R. K., Samarakoon, S. R., Manandhar, E., Yue, J. M., & Manandhar, M. D. (2023). Cytotoxicity of Compounds Isolated from Usnea aciculifera. Journal of Nepal Chemical Society, 43(2), 125–129. https://doi.org/10.3126/jncs.v43i2.53357

Issue

Vol. 43 No. 2 (2023)

Section

Research Article

License

© Journal of Nepal Chemical Society