Chemical Composition, Antibacterial, Antioxidant, and Cytotoxicity Activities of Essential Oil of Leaf of Ageratina adenophora (Spreng.) R.M. King and H. Rob.

Authors

  • Arjun Thapa Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Binita Maharjan Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Samjhana Bharati Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Timila Shrestha Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Puspa Lal Homagai Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Deval Prasad Bhattarai Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal
  • Ram Lal Swagat Shrestha Department of Chemistry, Amrit Campus, Institute of Science and Technology, Tribhuvan University, Lainchaur, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/jncs.v44i1.62692

Keywords:

Ageratina adenophora, Bioactivities, GC-MS, TFC, TPC

Abstract

Modern medicine recognizes the therapeutic applications of medicinal plants, which are utilized in indigenous therapies. Ageratina adenophora (Banmara) is an invasive plant growing in tropical and subtropical regions, traditionally used for treating wounds, sleeping disorders, jaundice, ulcers, etc. Using Clevenger apparatus for hydro-distillation, the essential oil was extracted, and gas chromatography-mass spectrometry (GC-MS) was used to determine its chemical constituents. GC-MS analysis of essential oil showed 14 possible compounds in which α-Muurolol (24.56%) was found to be most abundant. The essential oil exhibited a total phenolic content of 53.42 mg of gallic acid equivalent per gram of dry extract, while the total flavonoid content was determined to be 3.37 mg of quercetin equivalent per gram of dry extract. Essential oil of A. adhenophora showed a high antibacterial action against Staphylococcus aureus of ZOI of 12 mm. The antioxidant assay revealed weak activity of essential oil of IC50 17.21 mg/mL, while the brine shrimp lethality assay revealed its LC50 value to be 64.56 μg/mL.

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Published

2024-02-21

How to Cite

Thapa, A., Maharjan, B., Bharati, S., Shrestha, T., Homagai, P. L., Bhattarai, D. P., & Shrestha, R. L. S. (2024). Chemical Composition, Antibacterial, Antioxidant, and Cytotoxicity Activities of Essential Oil of Leaf of Ageratina adenophora (Spreng.) R.M. King and H. Rob. Journal of Nepal Chemical Society, 44(1), 173–182. https://doi.org/10.3126/jncs.v44i1.62692

Issue

Section

Research Article