Analysis of Predictors of Relapse in Children with Steroid Sensitive Nephrotic Syndrome

  • Mukesh Bhatta B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
  • Gauri Shankar Shah B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
  • Om Prakash Mishra Banaras Hindu University, Varanasi 221005
Keywords: Nephrotic syndrome, Factors, Relapses

Abstract

Introduction: Children with idiopathic nephrotic syndrome (INS) are steroid responsive but have relapses in subsequent non-treatment period. The objective of the present study was to analyze the factors which could predict relapses in these children.

Material and Methods: Forty patients of INS aged 1-14 years of both gender were enrolled over one year period and followed for six months after treatment of initial episode of Nephrotic Syndrome.

Results: The median age of children was 4.5 years and male to female ratio 1.9:1. There were 24(60%) relapses and 16(40%) non-relapses. The relapses had significantly higher mean total leukocyte count, serum urea, potassium and cholesterol than non-relapses. It was also observed that the median age of onset in relapses was significantly lower than non-relapses (p<0.001). Also, the median time to response to steroid therapy was longer in relapses than non-relapses (p<0.001). Children who relapsed had infections at the time of relapse.

Conclusion: Thus, onset of disease in younger age group, late response to steroid therapy and presence of infections were found to be associated with relapses in these children.

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Author Biographies

Mukesh Bhatta, B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
Resident, Department of Pediatrics and Adolescent
Medicine
Gauri Shankar Shah, B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
Professor, Department of Paediatrics and Adolescent
Medicine
Om Prakash Mishra, Banaras Hindu University, Varanasi 221005
Professor, Department of Paediatrics, Institute of Medical Sciences
Published
2017-10-04
How to Cite
Bhatta, M., Shah, G., & Mishra, O. (2017). Analysis of Predictors of Relapse in Children with Steroid Sensitive Nephrotic Syndrome. Journal of Nepal Paediatric Society, 37(1), 1-4. https://doi.org/10.3126/jnps.v37i1.17432
Section
Original Articles