Combination of Alarm-intervention and Reboxetine in Therapy- Resistant Enuresis

  • Kirill Kosilov Professor of Department of Social Sciences, School of Humanities, Far Eastern Federal University, and Professor of Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University
  • Irina Kuzina Head of the Department of Social Science, Far Eastern Federal University
  • Yuliya Gainullina Professor of Department of Social Sciences, School of Humanities, Far Eastern Federal University
  • Vladimir Kuznetsov Head of Department of Public Health of the Pacific State Medical University
  • Liliya Kosilova Doctor in the Department of Functional Diagnostics
  • Elena Viktorovna Karashchuk Department of Public Health, Pacific Medical University
  • Alexandra Prokofyeva Leading specialist of the Department of Social Sciences Far Eastern Federal University
  • Sergay Loparev Department of Urology, City polyclinic No 3
Keywords: Alarm intervention, Children and adolescents, Reboxetine

Abstract

Introduction: The first-line treatments of primary monosymptomatic night enuresis (PMNE) are alarm intervention and desmopressin. Some patients are resistant to these modes of treatment. Therefore Reboxetine has been used to treat PMNE in these scenarios in recent years and published in many studies. The aim of the study was to determine effectiveness and safety of combination of Alarm intervention and Reboxetine, to treat patients with therapyresistant enuresis.

Material and Methods: Two hundred and nineteen children of both sexes were participated in the experiment (average age, 11.3 years). Participants were divided into three groups: Group A (71 patients, Alarm intervention), Group B (79 patients, Reboxetine as monotherapy), Group C (69 patients, Alarm intervention + Reboxetine). The duration of treatment was twelve weeks, followed by follow-up period of twelve weeks to see efficacy.

Result: There was no significant change in number of enuresis episodes per week before and after treatment in a group B. The number of enuresis episodes per a week (weekly) in a group C reached: before treatment 5.3 (1.5), after treatment 1.0 (0.8), 3 three months after the end of treatment 0.7 (0.7). The percentage of patients with PMNE in a group C was significantly less immediately after the course of treatment (17.4%), and three months after treatment (24.6%).

Conclusion: Combined treatment of therapy-resistant enuresis with use of Alarm Intervention and Reboxetine gives a high percentage of cured patients both immediately after therapy (82.6%) and three months after the end (75.4%).

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Abstract
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Published
2018-06-07
How to Cite
Kosilov, K., Kuzina, I., Gainullina, Y., Kuznetsov, V., Kosilova, L., Karashchuk, E., Prokofyeva, A., & Loparev, S. (2018). Combination of Alarm-intervention and Reboxetine in Therapy- Resistant Enuresis. Journal of Nepal Paediatric Society, 37(3), 213-219. https://doi.org/10.3126/jnps.v37i3.18120
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Original Articles