A Randomized Trial of Ligustrazini Hydrochlorioi in the Treatment of Viral Encephalitis in Children

  • Fuyong Jiao Department of Paediatrics, Shaanxi Provincial People's Hospital, Xi'an
  • Xiangyang Guo Department of Paediatrics, Shaanxi Provincial People's Hospital, Xi'an
  • Jin Lin Department of Paediatrics, Shaanxi Provincial People's Hospital, Xi'an
  • Wei Cui Department of Paediatrics, The Second Teaching Hospital, Yan'an Medical College, Suide, Shaanxi
  • Huirong Li Department of Paediatrics, The Second Teaching Hospital, Yan'an Medical College, Suide, Shaanxi
Keywords: Cerebral Oedema, Encephalitis, Ligustrazini Hydrochlorioi

Abstract

Introduction: Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viral
encephalitis. In animal studies it has shown to inhibit the synthesis and activity of Thromboxane (TXA2)
and abate the imbalance between Thromboxane (TXA2) and Prostacyclin (PGI2). As a result, cerebral
edema, ischemia and hypoxia could be improved. The aim of this study is to evaluate its effect in the
treatment of viral encephalitis in children. Methodology: Ninety-nine patients with viral encephalitis
were randomly divided into two groups. Ligustrazini Hydrochlorioi (LH) consisting of 51 cases (males
30, females 21; age 5 years and nine month ±8 years and 2month) was given LH 4mg/kg per day in 100-
300mls of 10% glucose and infused intravenously over a three to four hour period, for 7 days as a course
of treatment. A control groups of 48 cases (males 31, females 17; age 5 years and three month ±4 years
and three month) received the conventional treatment of Vitamin C(2.0-3.0g), Coenzyme A(100u) and
Adenosine Triphosphate (ATP) (40mg) in 100-300 mls of 10% glucose infused intravenously daily for 7
days. Results: The total response rate in the LH group and the control group were 94.12% and 68.75%
respectively (u=3.271 p<0.05). The average time to improvement was 4.29±1.41 days and 7.31±2.66
days respectively. No adverse effect was observed in both groups. Conclusion: We conclude that LH is
an effective, safe and well tolerated treatment for children encephalitis.

Key words: Cerebral Oedema; Encephalitis; Ligustrazini Hydrochlorioi

DOI: 10.3126/jnps.v30i2.3451

J. Nepal Paediatr. Soc. May-August, 2010 Vol 30(2) 119-122

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Jiao, F., Guo, X., Lin, J., Cui, W., & Li, H. (1). A Randomized Trial of Ligustrazini Hydrochlorioi in the Treatment of Viral Encephalitis in Children. Journal of Nepal Paediatric Society, 30(2), 119-122. https://doi.org/10.3126/jnps.v30i2.3451
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Novel Therapy