Neonatal Screening for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Eastern India

Authors

  • Sweta Mukherjee Department of Paediatrics, Armed Forces Medical College, Pune, India
  • Ashish Mallige Department of Paediatrics, Command hospital (EC), Kolkata, India
  • Anupama Chowdhry Department of Physiology, Ex-Army College of Medical Sciences, New Delhi, India
  • Amit Devgan Department of Paediatrics, Armed Forces Medical College, Pune, India
  • Brajesh Singh Department of Pathology, Command Hospital (EC), Kolkata, India
  • Bhasker Mukherjee Department of Biochemistry, Armed Forces Medical College, Pune, India
  • Subhash Chandra Shaw Department of Paediatrics, Armed Forces Medical College, Pune, India

DOI:

https://doi.org/10.3126/jnps.v41i3.37153

Keywords:

Neonatal screening, Eastern India, G6PD deficiency

Abstract

Introduction: The overall magnitude of the frequency of G6PD deficiency ranges between 0 to 10 percent in the Indian population. This prospective study was planned to estimate the prevalence of G6PD deficiency in newborn population born in a tertiary care centre in Eastern India.

Methods: This prospective observational study was undertaken among all consecutively delivered neonates born in a tertiary care teaching hospital of Eastern India, between Apr 2016 and Oct 2017. Prematurity less than 32 weeks and perinatal asphyxia requiring extensive resuscitation were excluded from the study. Umbilical cord blood samples were collected in a EDTA containers, drawn from the placental side of the umbilical cord incised while severing it at the time of birth. The G6PD levels were estimated quantitatively based on ultraviolet (UV) method by quantitative sphectrophotometric assay using ILab 650 fully automated analyzer. All babies wherein the cord blood G6PD levels was less than 6.95 mU/g of Hb was taken as deficient. 

Results: Mean (SD) of G6PD at birth was 12.56 (3.45) mU/g of Hb. Out of 1037 neonates, five were found to be G6PD deficient. There was increased incidence of neonatal jaundice requiring phototherapy in G6 PD deficient neonates, and it was statistically significant.

Conclusion: The prevalence of G6PD deficiency was 0.48% in term and late preterm neonates as assessed quantitatively in cord blood

Downloads

Download data is not yet available.
Abstract
188
PDF
187

Downloads

Published

2021-12-31

How to Cite

Mukherjee, S., Mallige, A., Chowdhry, A., Devgan, A., Singh, B., Mukherjee, B., & Shaw, S. C. (2021). Neonatal Screening for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Eastern India. Journal of Nepal Paediatric Society, 41(3), 408–412. https://doi.org/10.3126/jnps.v41i3.37153

Issue

Vol. 41 No. 3 (2021)

Section

Original Articles

License

Copyright (c) 2021 Sweta Mukherjee, Ashish Mallige, Anupama Chowdhry, Amit Devgan, Brajesh Singh, Bhasker Mukherjee, Subhash Chandra Shaw

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).