Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome

Authors

  • P Goyal Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi
  • R Singh Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi
  • A Yadav Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi
  • AK Dutta Department of Paediatrics, Kalawati Saran Children’s Hospital, Lady Hardinge Medical College, New Delhi
  • J Bhattacharjee Department of Paediatrics, Kalawati Saran Children’s Hospital, Lady Hardinge Medical College, New Delhi

DOI:

https://doi.org/10.3126/jnps.v30i3.3919

Keywords:

Chromosome 21, Down Syndrome, Trisomy 21, Superoxide dismutase

Abstract

Introduction: Down Syndrome (trisomy 21) provides an interesting natural model to study atherosclerosis, since these individuals appear to be protected from plaque formation.

Methodology: We assessed the lipid levels, and superoxide dismutase (SOD) activity in 32 clinically diagnosed children of Down syndrome and 34 children matched for age and sex as controls.

Results: SOD activity was found to be significantly higher (p=0.004) in children with Down Syndrome (mean=313.7 IU/ml) than in controls (mean140.2 IU/ ml). Significantly higher levels of serum triglyceride (154.7 mg/dl) and VLDL (33.9 mg/dl) were observed in Down Syndrome as compared to healthy controls (119.6 mg/dl and 23.9 mg/dl respectively; p<0.05 for each). However, the two groups did not show any significant difference in levels of serum HDL-C, LDL-C.

Conclusion: The raised antioxidant activity of SOD, because of over expression of genes situated non chromosome 21, probably offers some protection against the development of atherosclerosis despite the occurrence of dyslipidemia.

Key words: Chromosome 21; Down Syndrome; Trisomy 21; Superoxide dismutase.  

DOI: 10.3126/jnps.v30i3.3919

J Nep Paedtr Soc 2010;30(3):160-163

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How to Cite

Goyal, P., Singh, R., Yadav, A., Dutta, A., & Bhattacharjee, J. (2010). Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome. Journal of Nepal Paediatric Society, 30(3), 160–163. https://doi.org/10.3126/jnps.v30i3.3919

Issue

Vol. 30 No. 3 (2010)

Section

Original Articles

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