Histiocytosis: An Uncommon Presentation with Hypopituitarism

  • SK Kota Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh
  • S Jammula Roland Institute of Pharmaceutical Sciences Berhampur, Orisssa
  • PR Tripathy Kalinga Institute of Medical Sciences Bhubaneswar, Orissa
  • Siva Krishna Kota Central Security Hospital Riyadh
  • LK Meher Head, Department of Medicine, MCKG Medical College, Berhampur, Orissa
  • K Modi Head, Department of Endocrinology, Medwin Hospital, Hyderabad, Andhrapradesh
Keywords: Histiocytosis, Diabetes inspidus, Growth hormone deficiency, Central hypothyroidism

Abstract

Langerhans cell histiocytosis is a multi system disorder with a certain predilection for involving hypothalamic pituitary axis. We hereby report a 7 year old girl presenting with polyuria, polydipsia and growth retardation. The girl had a past history of pain in right hip joint and nodular region over chest. Water deprivation test confirmed the diagnosis of central diabetes inspidus. Other investigations revealed Growth hormone deficiency and central hypothyroidism. X-ray and MRI hip revealed absent right inferior pubic ramus with bone marrow biopsy confirming the diagnosis of histiocytosis. Patient was treated with nasal Arginine Vasopressin spray, subcutaneous growth hormone and oral thyroxine.

Key words: Histiocytosis; Diabetes inspidus; Growth hormone deficiency; Central hypothyroidism

DOI: http://dx.doi.org/10.3126/jnps.v32i1.5343

J. Nepal Paediatr. Soc. Vol.32(1) 2012 81-84

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Author Biography

Siva Krishna Kota, Central Security Hospital Riyadh

Anesthesia

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Published
2012-02-29
How to Cite
Kota, S., Jammula, S., Tripathy, P., Kota, S., Meher, L., & Modi, K. (2012). Histiocytosis: An Uncommon Presentation with Hypopituitarism. Journal of Nepal Paediatric Society, 32(1), 81-84. https://doi.org/10.3126/jnps.v32i1.5343
Section
Brief Reports/Case Reports/Case Series