Role of Lumbar Puncture in Late Onset Neonatal Sepsis

Authors

  • Amit Kumar Das Indira Gandhi Memorial Hospital, Male, Maldives
  • Deepak Mishra Kanti Children’s Hospital, Maharajgunj, Kathmandu, Nepal
  • Nitu Kumari Jha National Academy of Medical Sciences, Kathmandu, Nepal
  • Rakesh Mishra NAMS, Kathmandu, Nepal
  • Soniya Jha Ramlal Golchha Eye Hospital, Morang, Nepal

DOI:

https://doi.org/10.3126/jnps.v39i3.28459

Keywords:

CSF examination, late-onset sepsis, lumbar puncture

Abstract

Introduction: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life.  It is responsible for about 30-50% of the total neonatal deaths in developing countries.  Neonatal sepsis can be divided into two sub-types depending upon whether the onset of symptoms within the first 72 hours of life (Early Onset Neonatal Sepsis) or after 72 hours of life (Late Onset Neonatal Sepsis ).  Meningitis is an important complication of late onset neonatal sepsis.

Method: This was hospital based prospective observational study conducted among the neonates admitted with diagnosis of late onset neonatal sepsis in Neonatal Intermediate Care Unit (NIMCU) and Neonatal Intensive Care Unit (NICU) of Kanti Children’s Hospital from July 2016 to June 2017. The objective of this study was to evaluate the importance of performing LP in neonates with LONS.

Results: 16.8% neonates with late onset neonatal sepsis were found to have meningitis. Among the neonates with meningitis CRP was positive 57.2% and negative in 42.8 %.  Among the cases with abnormal CSF findings, blood culture was sterile in 85% cases and organism was isolated 15% cases. In 88.8% cases with positive blood culture, no meningitis was detected. Lumbar puncture was traumatic in 1 neonate (0.8%) in first attempt. Apart from this no other complication of performing lumbar puncture was noted.

Conclusion: Lumbar puncture and CSF examination is mandatory in all cases with late-onset sepsis.

Downloads

Download data is not yet available.
Abstract
13
PDF
13

Author Biographies

Amit Kumar Das, Indira Gandhi Memorial Hospital, Male, Maldives

Consultant Paediatrician, Department of Paediatrics

Deepak Mishra, Kanti Children’s Hospital, Maharajgunj, Kathmandu, Nepal

Department of Paediatrics

Nitu Kumari Jha, National Academy of Medical Sciences, Kathmandu, Nepal

Department of Obstretics and Gynaecology

Rakesh Mishra, NAMS, Kathmandu, Nepal

Department of Orthopaedics

Soniya Jha, Ramlal Golchha Eye Hospital, Morang, Nepal

Medical Officer

Cover JNPS

Downloads

Published

2019-12-31

How to Cite

Das, A. K., Mishra, D., Jha, N. K., Mishra, R., & Jha, S. (2019). Role of Lumbar Puncture in Late Onset Neonatal Sepsis. Journal of Nepal Paediatric Society, 39(3), 155–161. https://doi.org/10.3126/jnps.v39i3.28459

Issue

Vol. 39 No. 3 (2019)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).