Bruton’s X-Linked Agammaglobulinemia Presenting as Chronic Monoarticular Arthritis
Bruton’s X-Linked Agammaglobulinemia (XLA) is an X linked recessive primary immune deficiency disorder characterized by recurrent bacterial infections and failure to generate immunoglobulins of all isotypes due to the absence or profoundly decreased mature B cells and plasma cells, secondary to mutations in the Bruton’s tyrosine kinase (Btk) gene. The coexistence of chronic monoarticular arthritis in a patient with Bruton’s XLA has been described an uncommon presentation. We describe a 5 year-old boy with XLA and chronic monoarticular arthritis.
J. Nepal Paediatr. SocVol.32(3) 2012 245-249
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