Comparative Study of Diagnostic Markers in Neonatal Sepsis

Authors

  • Vijay Baburao Sonawane MBBS, MD, Assistant Professor, Department of Paediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra
  • Sonali U Gaikwad Department of Paediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra
  • Nitin N Kadam Department of Paediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra
  • Jitendra Gavhane Department of Paediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra

DOI:

https://doi.org/10.3126/jnps.v34i2.9788

Keywords:

Neonatal Sepsis, Diagnostic Markers, Mortality

Abstract

Introduction: Neonatal septicemia is one of the commonest causes of neonatal mortality and morbidity. The objectives of this study were intended for qualitative and quantitative analysis of diagnostic markers in neonatal sepsis.

Materials and Methods: This is a hospital based study conducted over three years (Aug 2005 – Aug 2008). Hundred and sixty neonates, delivered in the hospital, having risk factors for neonatal sepsis, along with those coming to hospital with signs and symptoms of sepsis up to 28 days of life (as study group ) along with normal newborns admitted to the postnatal ward without high risk factors (control group) were enrolled for this study. Comparative study on various diagnostics markers such blood culture, CBC,CRP, IT ratio and Micro-ESR was carried out to know their sensitivity and specificity.

Results: E.Coli was the most common organism responsible for sepsis. CRP was reported to be highly sensitive (84.21%), and CBC was highly specific (75.00%), IT ratio has sensitivity of 62.5% and specificity of 56.25% while Micro-ESR has shown sensitivity of 50.0% and specificity of 62.5%,Out of 160 cases, blood culture (BacTalert) showed growth in48 cases in study group while two cases in control group. Thus blood culture positivity was 60%.

Conclusion: Blood culture is the gold standard for the diagnosis of septicemia. CRP is most sensitive while CBC is most specific marker in neonatal sepsis.

DOI: http://dx.doi.org/10.3126/jnps.v34i2.9788

J Nepal Paediatr Soc 2014;34(2):111-114 

 

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Author Biography

Vijay Baburao Sonawane, MBBS, MD, Assistant Professor, Department of Paediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra

 ASST.PROFESSOR IN PEDIATRICS

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Published

2014-10-30

How to Cite

Sonawane, V. B., Gaikwad, S. U., Kadam, N. N., & Gavhane, J. (2014). Comparative Study of Diagnostic Markers in Neonatal Sepsis. Journal of Nepal Paediatric Society, 34(2), 111–114. https://doi.org/10.3126/jnps.v34i2.9788

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Original Articles