Clinico-histopathological analysis of orbito-ocular lesions: a hospital-based study

Authors

  • Santosh Upadhyaya Kafle Birat Medical College and Teaching Hospital, Morang, Nepal
  • Mrinalini Singh Birat Medical College and Teaching Hospital, Morang, Nepal
  • Prerna Arjyal Kafle Biratnagar Eye Hospital, Morang, Nepal
  • Bal Kumar KC Birat Eye Hospital, Morang, Nepal
  • Sanjeev Kumar Yadav Birat Eye Hospital, Morang, Nepal
  • Anadi Khatri KC Birat Medical College and Teaching Hospital, Morang, Nepal

DOI:

https://doi.org/10.3126/jpahs.v6i2.27228

Keywords:

ancillary techniques, clinico-pathological correlation, immunohistochemistry, orbito-ocular lesions, squamous cell carcinoma

Abstract

Introductions: Preoperative diagnosis of orbital and ocular lesions is necessary for optimum treatment. The study aims to analyze the histomorphological spectrum of orbito-ocular lesions and to evaluate the need of ancillary techniques for confirmation of diagnosis.

Methods: A cross sectional hospital based study of orbito-ocular surgical biopsy samples obtained in the Department of Pathology, at Birat Medical College Teaching Hospital, Nepal during one-year period was analysed for clinical and histopathological findings. Demographic data, site and tissue type, benign or malignant, recommendations for special stains and immunohistochemistry panel study were analysed.

Results: Out of 185 total samples, male to female ratio of 1.1:1, age ranged from ten month to 82 years, 11-20 year age group had 39 (21.1%) orbito-ocular lesions and cornea-conjunctiva was involved in 104 (56.2%). Clinical diagnosis correlated well with histopathological diagnosis, p<0.001. The non-neoplastic, benign and malignant lesions were 36.7%, 33.5% and 29.7% respectively. Squamous cell carcinoma was seen in 28 (50.9%) of malignant lesions followed by sebaceous carcinoma 7 (12.7%). The special stains and immunohistochemistry panel was recommended in 38 (20.5% and 21 (11.3%) cases respectively.

Conclusions: Findings suggest the clinical and histopathological diagnosis correlated well in diagnosis of a wide spectrum of orbito-ocular lesions.

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Author Biographies

Santosh Upadhyaya Kafle, Birat Medical College and Teaching Hospital, Morang, Nepal

Assoc. Prof., Department of Pathology

Mrinalini Singh, Birat Medical College and Teaching Hospital, Morang, Nepal

Asst. Prof., Department of Pathology

Prerna Arjyal Kafle, Biratnagar Eye Hospital, Morang, Nepal

Ophthalmologist

Bal Kumar KC, Birat Eye Hospital, Morang, Nepal

Ophthalmologist

Sanjeev Kumar Yadav, Birat Eye Hospital, Morang, Nepal

Ophthalmologist

Anadi Khatri KC, Birat Medical College and Teaching Hospital, Morang, Nepal

Lecturer, Department of Ophthalmology

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Published

2019-12-31

How to Cite

Kafle, S. U., Singh, M., Kafle, P. A., KC, B. K., Yadav, S. K., & KC, A. K. (2019). Clinico-histopathological analysis of orbito-ocular lesions: a hospital-based study. Journal of Patan Academy of Health Sciences, 6(2), 39–44. https://doi.org/10.3126/jpahs.v6i2.27228

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Section

General Section: Original Articles