COVID-19 impact on liver: inter-organ cross-talk in an acute inflammation

Authors

DOI:

https://doi.org/10.3126/jpahs.v8i2.28838

Keywords:

Coronavirus, COVID-19, Liver Disease, Liver Failure, Liver Injury, SARS-CoV-2

Abstract

Since coronavirus disease 2019 (COVID-19) has been a new disease, very less is known about the disease, and guidance for the treatment are often being made on the basis of an experiences or expert opinions. Now it is known that COVID-19 is caused by a new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus which elicit infection to the cells by binding of the spike protein to angiotensin converting enzyme 2 (ACE2). Given the high transmissibility rate of the SARS-Cov-2 virus and known to have cytokine dysregulation by inducing an immune-mediated systemic inflammation, patients with underlying liver disease might be at an increased risk of severe infection and death. Here we report different mechanisms based on the organ cross-talk and other causes that how COVID-19 patients are prone to have liver injury.

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Author Biographies

Dipesh Kumar Yadav, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Postdoctoral Researcher, Department of Hepatobiliary Surgery & Liver Transplantation

Alina Singh, Pokhara Medical Clinic, Pokhara, Nepal

Medical Officer, Department of Surgery

Rajesh Kumar Yadav, Gandaki Medical College Teaching Hospital and Research Centre, Pokhara, Nepal

Associate Professor, Department of Pharmacology

Huang Xing, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Professor, Department of Hepatobiliary Surgery & Liver Transplantation

Bai Xue Li, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Professor, Department of Hepatobiliary Surgery & Liver Transplantation

Liang Tingbo, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Professor, Department of Hepatobiliary Surgery & Liver Transplantation

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Published

2021-08-31

How to Cite

Yadav, D. K., Singh, A., Yadav, R. K., Xing, H., Li, B. X., & Tingbo, L. (2021). COVID-19 impact on liver: inter-organ cross-talk in an acute inflammation. Journal of Patan Academy of Health Sciences, 8(2), 49–57. https://doi.org/10.3126/jpahs.v8i2.28838

Issue

Section

COVID-19: Review Articles