Antibiotic susceptibility pattern of staphylococcus aureus and methicillin-resistant staphylococcus aureus in a tertiary care hospital

  • CP Bhatt Department of Microbiology, Kathmandu Medical College Public Limited, Sinamangal Kathmandu
  • BMS Karki Department of Microbiology, Kist Medical College, Gwarkhu
  • B Baral Department of Microbiology, Nobel College, Kathmandu
  • S Gautam Department of Microbiology, Nobel College, Kathmandu
  • A Shah Department of Microbiology, Nobel College, Kathmandu
  • A Chaudhary Department of Microbiology, Nobel College, Kathmandu
Keywords: Nosocomial infection, MRSA, Staphylococcus aureus

Abstract

Background: Methicillin resistant Staphylococcus aureushas emerged as one of the most important nosocomial pathogens. It invokes a tremendous financial burden and enhanced morbidity and mortality due to difficult to treat systemic infections.Aim of this study was to determine antibiotic susceptibility pattern of Staphylococcus aureus and Methicillin resistant Staphylococcus aureus.

Materials and Methods: Different clinical specimens were collected and processed for routine culture and antibiotic sensitivity test by standard microbiology techniques.

Results: Out of 1173 samples received for microbiological examination, 100 were found to be S. aureus with 19% cases were Methicillin resistant Staphylococcus aureus (MRSA). Fourteen MRSA were found from inpatient and 5 were from outpatient. MRSA was found higher in female than male and maximum number (31.5%) was found in age group 0-10 years. Staphylococcus aureus was 100% sensitive to Vancomycin followed by Amikacin (90%), Gentamycin (83%), and tetracycline (81%). On urine isolates Nitrofurantoin(91.6%) was drug of choice. All the isolates were resistant to Penicillin G. In case of Methicillin resistant Staphylococcus aureus showed 100% sensitive to Vancomycin followed by Amikacin (84.2%), Tetracycline (63.1%), Ciprofloxacin (42%) and Gentamycin (36.8%). Among urine isolates Nitrofutantoin showed 87.5% sensitive followed by Norfloxacin (75%).

Conclusion: Methicillin resistant Staphylococcus aureus was found 19% of Staphylococcus aureus isolates. It was most common in females, hospitalized patients and young age group. Vancomycin seems to be drug of choice followed by Amikacin. It would be helpful to formulating and monitoring the antibiotic policy and ensure proper empiric treatment.

DOI: http://dx.doi.org/10.3126/jpn.v4i7.10297

Journal of Pathology of Nepal (2014) Vol. 4, 548-551  

 

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Published
2014-04-25
How to Cite
Bhatt, C., Karki, B., Baral, B., Gautam, S., Shah, A., & Chaudhary, A. (2014). Antibiotic susceptibility pattern of staphylococcus aureus and methicillin-resistant staphylococcus aureus in a tertiary care hospital. Journal of Pathology of Nepal, 4(7), 548-551. https://doi.org/10.3126/jpn.v4i7.10297
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Original Articles