Correlation between Robinson’s cytological grading with Modiied Bloom-Richardson histopathological grading for breast carcinoma

  • S Chalise Kathmandu Medical College, Sinamangal and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
  • A Jha Institute of Medicine, Maharajgunj and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
  • PR Neupane Bhaktapur Cancer Hospital, Bhaktapur, Nepal
  • SB Pradhan Kathmandu Medical College, Sinamangal, Nepal
  • R Pathak Nepal Medical College, Jorpati and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
Keywords: Fine needle aspiration cytology, Robinson’s cytological grading, Modified Bloom-Richardson grading

Abstract

Background: Invasive breast carcinoma is the most common carcinoma in women. Fine needle aspiration cytology is the important part of triple assessment of the palpable breast lump. Robinson’s cytological grading can be done in fine needle cytology smears of breast lump. The aim of this study is to grade breast tumor on cytology according to Robinson cytological grading and to correlate with histopathological grading.

Materials and methods: This prospective study was done in Department of pathology, Bhaktapur Cancer Hospital from 1st April 2014 to 30thjuly 2015. A total of 58 cases of cytologically confirmed breast carcinoma were included in this study and correlated with histopathological findings. Robinson’s cytological grading was done on cytology smears and modified Bloom-Richardson grading was done on histological sections. Correlation between these two grading was done by using spearman’s correlation coefficient.

Results: Cytologically, most common tumor was grade II (62.1%) followed by grade I (19%) and grade III (19%). Histologically, most common tumor was grade II (63.8%) followed by grade III (22.4%) and grade I (13.8%). High concordance rate was found in grade II tumor (80%) with absolute concordance being 65.9%. On cytology, cell dissociation and nuclear margin were determining features (p<0.005). Correlation between cytological grading and histological grading was statistically significant (p<0.005).

Conclusion:  Robinson’s cytological grading is the easy grading method that can be done on cytology smears of the breast carcinoma to achieve relevant information regarding aggressiveness of the tumor and to plan for neoadjuvant chemotherapy preoperatively.

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Author Biographies

S Chalise, Kathmandu Medical College, Sinamangal and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
Pathology
A Jha, Institute of Medicine, Maharajgunj and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
Pathology
PR Neupane, Bhaktapur Cancer Hospital, Bhaktapur, Nepal
Surgery
SB Pradhan, Kathmandu Medical College, Sinamangal, Nepal
Pathology
R Pathak, Nepal Medical College, Jorpati and Bhaktapur Cancer Hospital, Bhaktapur, Nepal.
Pathology
Published
2015-09-14
How to Cite
Chalise, S., Jha, A., Neupane, P., Pradhan, S., & Pathak, R. (2015). Correlation between Robinson’s cytological grading with Modiied Bloom-Richardson histopathological grading for breast carcinoma. Journal of Pathology of Nepal, 5(10), 791-797. https://doi.org/10.3126/jpn.v5i10.15659
Section
Original Articles