Can p53 expression and staining intensity correlate with histopathological prognostic parameter and clinical staging in head and neck squamous cell carcinoma?

Authors

  • Jasmeet Kaur Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India http://orcid.org/0000-0001-9856-9542
  • Rahul Mannan Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Mridu Manjari Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Sonam Sharma Kalpana Chawla Government Medical College, Karnal, Haryana, India.
  • Jasmine Kaur Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India
  • Tejinder Singh Bhasin Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Amritpal Kaur Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

DOI:

https://doi.org/10.3126/jpn.v7i2.17976

Keywords:

Head and Neck, p53, Immunoexpression, Intensity, Squamous Cell Carcinoma,

Abstract

Background: In recent years, p53 has emerged as an important tool for not only diagnosis and predicting prognosis in head and neck squamous cell carcinoma. The aim of this study was to find the role of p53 staining intensity in determining prognosis. 

Materials and Methods: Fifty histopathologically proven cases of squamous cell carcinoma of head and neck were studied. The findings of the study were analyzed particularly in reference to p53 expression and their correlation with age, sex, anatomical site, tumor size, histological grading, vascular, peri-neural, muscle invasion, lymph node metastasis and staining intensity.

Results: Immunopositivity rate of p53 was 64% with percentage positive cells varying from 5-76% with mild, moderate and strong staining intensity. A positive correlation of p53 independently was seen with oral cavity, grade, lymph node metastasis and pathological staging.

Conclusion: p53 immunoexpression is an important independent variable of prognostication.

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Author Biographies

Jasmeet Kaur, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Pathology

Rahul Mannan, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Pathology

Mridu Manjari, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Pathology

Sonam Sharma, Kalpana Chawla Government Medical College, Karnal, Haryana, India.

Pathology

Jasmine Kaur, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India

Oral and Maxillo-Facial Surgery

Tejinder Singh Bhasin, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Pathology

Amritpal Kaur, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Pathology

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Published

2017-09-01

How to Cite

Kaur, J., Mannan, R., Manjari, M., Sharma, S., Kaur, J., Bhasin, T. S., & Kaur, A. (2017). Can p53 expression and staining intensity correlate with histopathological prognostic parameter and clinical staging in head and neck squamous cell carcinoma?. Journal of Pathology of Nepal, 7(2), 1141–1148. https://doi.org/10.3126/jpn.v7i2.17976

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Original Articles

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